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Evaluating Isradipine for Cognitive Enhancement in Schizophrenia and Schizoaffective Disorder

Schizophrenia Clinical Trial

Official title:
A Molecular Approach to Treat Cognition in Schizophrenia: Ca2+ Channel Blockade

Clinical Trial Summary

The purpose of this study is to evaluate the use of the drug isradipine for cognitive enhancement in patients diagnosed with schizophrenia and schizoaffective disorder.

Clinical Trial Description

The purpose of this study is to evaluate the use of the drug isradipine for cognitive enhancement in patients diagnosed with schizophrenia and schizoaffective disorder. Incomplete treatment response can be common in these disorders. While there are medications that are effective at treating positive symptoms, some other symptoms of the disorders are often left only partially treated (cognitive impairment and negative symptoms). This study will begin to address if the medication isradipine might help to treat some of the cognitive problems associated with schizophrenia and schizoaffective disorder. Isradipine is a medication that acts by blocking a specific type of receptor in the brain called a calcium channel. It is currently approved by the FDA for hypertension. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01658150
Study type Interventional
Source Icahn School of Medicine at Mount Sinai
Contact
Status Completed
Phase N/A
Start date September 2012
Completion date January 2, 2018
View Details
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