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Uppsala Psychosis Cohort — UPC  

Schizophrenia; Psychosis Clinical Trial

Official title:
Uppsala Psychosis Cohort: A Multimodal Study in Early Stage Psychosis Patients, High Risk Individuals and Healthy Controls

Clinical Trial Summary

A multimodal longitudinal study in early stage psychosis patients and individuals at high risk for psychosis. Healthy controls are included for baseline comparisons. The aim is to investigate disease mechanisms of psychotic disorders, specifically focusing on the synaptic pruning hypothesis.

Clinical Trial Description

This is a single-site observational study examining synaptic density using positron emission tomography (PET) and the radioligand [18F]SynVest-1 binding to the synaptic vesicle glycoprotein 2A. In addition to PET, the study includes clinical assessment, cognitive testing, multimodal magnetic resonance imaging (MRI) measures, neurophysiological measures, lumbar punction for cerebrospinal fluid (CSF) analyses, blood sampling, heart rate variability measures. Early stage psychosis patients and clinical high-risk individuals are subject to repeat assessment after 1 year (including PET), and at 3 and 5 years. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05763966
Study type Observational
Source Uppsala University
Contact Simon Cervenka, MD, PhD
Phone +46709944226
Email simon.cervenka@neuro.uu.se
Status Not yet recruiting
Phase
Start date March 15, 2023
Completion date December 31, 2031
View Details
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