Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension

Pulmonary Hypertension Clinical Trial

Official title:

Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03564522
• Other study ID #: HUM00117706
• Secondary ID: U01HL135842
• Status: Completed
• Start date: April 1, 2017
• Est. completion date: July 28, 2023

Study information

• Verified date: April 2024
• Source: University of Michigan
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study looks to develop a multi-scale computational model of Pulmonary Hypertension, this clinical model will be calibrated using longitudinal, retrospectively and prospectively acquired human clinical data.

Description:

Pulmonary hypertension (PH) is a complex disorder associated with elevated pulmonary arterial pressure. Unlike systemic hypertension, PH is difficult to detect in routine physical examinations and the current gold standard for diagnosing PH is through invasive right heart catheterization. Prolonged PH results in functional, structural and anatomical changes in the right ventricle (RV), large pulmonary arteries, and the pulmonary micro-circulation that ultimately lead to decompensated RV failure and death. Unlike in systemic hypertension, for which patients have effective pharmacological management of blood pressure for decades, PH prognosis remains poor with 15% mortality within 1 year on modern therapy. Our current understanding of PH has largely been obtained through animal models and clinical studies. However, surgical banding or chronic hypoxia animal models do not fully reproduce the etiology of human PH, whereas invasive clinical measurements of pulmonary vascular resistance (PVR), stiffness and ventricular elastance provide limited insight into disease progression. Therefore, there is a pressing need to develop a multi-scale (MS) computational model that can couple the short term (e.g. hemodynamics) and long-term G&R interactions between the RV and the pulmonary circulation.

The overall goals of this project are to use the framework to (1) describe the time course of the biomechanical alterations and (2) identify the key mechanical culprits associated with PH-induced heart failure so that clinical interventions can be targeted against them.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 35
• Est. completion date: July 28, 2023
• Est. primary completion date: July 28, 2023
• Gender: All
• Age group: 6 Years to 25 Years

Eligibility

Inclusion Criteria:

• Patients has been clinically diagnosed with pulmonary hypertension (>25 mmHg) or patient is a biopsy-proven non-rejecting cardiac transplant recipient

• Receiving partial or full care from pediatric cardiology team at Mott Children's Hospital (may have a primary cardiologist elsewhere).

Exclusion Criteria:

• Girls and women who are pregnant or actively trying to become pregnant

• Patients with significant neurocognitive impairment that precludes their ability to sign a consent form

• Patient has a contraindication to right-heart catheterization (RHC) examination, which includes patients with hypoxia and those who have difficulty maintaining supine position for the procedure.

• Patients with the following genetic syndromes:Trisomy 21 if unable to assent or consent, Trisomy 18,Trisomy 13, Other genetic syndromes at the discretion of the Primary Investigator

• Patients with unrepaired single ventricles (i.e., Pre-Fontan physiology)

• Patients who have heart failure and are deemed to be high risk to undergo tests that require sedation/anesthesia.

• Patients who require IV sedation or general anesthesia for research only MRI

• Patients with a pacemaker/internal defibrillator will be excluded from MRI PORTION ONLY

Related Conditions & MeSH terms

• Congenital Heart Disease
• Heart Defects, Congenital
• Heart Diseases
• Hypertension
• Hypertension, Pulmonary
• Pediatric Congenital Heart Disease
• Pulmonary Hypertension

Intervention

Procedure:
• cardiac catheterization
cardiac catheterizations will be clinically indicated and the study will collect this clinical data.

Radiation:
• Cardiac MRI
If clinically indicated, the study will collect data from MRIs.

Locations

Country	Name	City	State
United States	Mott Children's Hospital University of Michigan	Ann Arbor	Michigan
United States	Nationwide Children's Hospital	Columbus	Ohio

Sponsors (4)

Lead Sponsor	Collaborator
University of Michigan	Michigan State University, National Heart, Lung, and Blood Institute (NHLBI), Nationwide Children's Hospital

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	3D volumetric data (mL/m2)	Modeling framework will be validated using 3D volumetric data (mL/m2) gathered via cardiac MRI	1 hour
Primary	Cardiopulmonary Flow (mL/beat)	Modeling framework will be validated using cardiopulmonary flow (mL/beat) gathered via cardiac MRI	1 hour
Primary	Mean Pressure (mmHg)	Modeling framework will be validated using pressures (mmHg) gathered via cardiac catheterization	2 hours