Pulmonary Hypertension Clinical Trial
Official title:
Magnetic Resonance Imaging in the Diagnosis of Pulmonary Hypertension
The aim of the present study is to identify changes in the cardiovascular system in patients
with pulmonary hypertension (PH) by magnetic resonance imaging (MRI). MRI is accepted as
golden standard method for the evaluation of left and right ventricular morphology and
function.
All patients who showed elevated pulmonary pressure in the right heart catheter
investigation are assigned to MRI. Parameters derived from MRI are included in the clinical
and therapeutic decisions. Well established as well as new MRI parameters are evaluated and
compared to the results of right heart catheter. Further age-matched controls without known
cardiac or pulmonary disease are investigated by native MRI.
Patients with suspected, latent and manifest PH and controls are investigated by MRI
according to the following protocol in breathhold or free breathing (depending on the
patients' breath-hold abilities). In case of elevated Creatinin values, no contrast agent is
applied.
- Planning of cardiac views: Planning of 2-chamber view, short axes view and 4-chamber
view.
- Morphological overview: Transversal and coronal Haste images
- Left and right heart functional and valve evaluation: Cine 2-chamber imaging,
Multi-slice cine 4-chamber imaging, Cine Left and Right ventricular outflow tract
imaging and Multi-slice cine short axes imaging covering the left and right ventricle
for evaluation of EDV, ESV, SV, EF, CO and muscle mass.
- Phase Contrast Imaging: Flow measurements in the aorta, the pulmonary artery and the
heart.
- Perfusion measurement.
- Late enhancement measurement: Multi-slice short axes view, multi-slice 2-chamber view
and multi-slice 4-chamber view.
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N/A
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