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Evaluation of Anti-Xa Levels in Surgery Patients Receiving Weight-based Heparin

Pulmonary Embolism Clinical Trial

Official title:
Evaluation of Anti-Xa Levels in Surgery Patients Receiving Weight-based Heparin

Clinical Trial Summary

The purpose of this study is to determine if weight-based heparin infusions at a rate of 10 units/kg/hour are sufficient to maintain a target anti-Xa of 0.1-0.35 IU/mL for VTE prophylaxis in patients undergoing microvascular surgery. Additionally, a pilot protocol has been developed to titrate these heparin infusions to ensure patients have sufficient VTE prophylaxis. All patients will be enrolled in the observational arm of the study and receive anti-Xa level monitoring. Patients with out-of-range anti-Xa levels will cross over to the interventional arm of the study and receive real time heparin infusion dose adjustments per the pilot protocol. The primary outcome measured will be the percentage of patients with anti-Xa levels in the target range of 0.1-0.35 IU/mL while on a heparin infusion at 10 units/kg/hour.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03516656
Study type Interventional
Source University of Utah
Contact
Status Completed
Phase Early Phase 1
Start date March 23, 2018
Completion date August 24, 2021
View Details
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