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Prostatic Neoplasms clinical trials

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NCT ID: NCT00247312 Completed - Prostatic Neoplasm Clinical Trials

Pd-103 Dose De-Escalation for Early Stage Prostate Cancer: A Prospective Randomized Trial

Start date: October 2005
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine the most appropriate radiation implant dose for palladium-103 monotherapy. Radiation dose is related to potential cure. From previously published studies, it appears that the prescribed radiation dose can be reduced by 14-20% without any difference in potential cure (in this study, the dose is being decreased 10%). Although most patients tolerate brachytherapy well, complications to appear to be related to radiation exposure to normal structures (i.e. urethra, rectum and proximal penis). By reducing the prescribed dose, it is conceivable that fewer patients will experience side effects and complications.

NCT ID: NCT00246753 Completed - Prostate Cancer Clinical Trials

Lapatinib in Treating Patients With Prostate Cancer That Did Not Respond to Hormone Therapy

NRR
Start date: October 2005
Phase: Phase 2
Study type: Interventional

RATIONALE: Lapatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase II trial is studying how well lapatinib works in treating patients with prostate cancer that did not respond to hormone therapy.

NCT ID: NCT00245895 Completed - Prostate Cancer Clinical Trials

Study of Aranesp to Treat Anemia in Prostate Cancer Patients.

Start date: April 2003
Phase: Phase 2
Study type: Interventional

The purpose of this study is to see if darbepoetin alfa is an effective treatment for anemia in prostate cancer patients and, if so, what dose is most effective. Sometimes prostate cancer patients have low red blood cell counts (low hemoglobin) from various treatments they are receiving, such as chemotherapy. The red blood cells deliver oxygen to the tissue. This then helps give the patient more energy.

NCT ID: NCT00245518 Completed - Hot Flashes Clinical Trials

Effect of Soy on Cognition and Hot Flashes in Men With Prostate Cancer Undergoing Testosterone Suppression Therapy

Start date: June 2005
Phase: Phase 4
Study type: Interventional

This study will look at the effects of a soy supplement called Revival on memory, quality of life, and hot flashes in men with prostate cancer who are being treated with testosterone suppression therapy. Hypothesis: Treating men who have prostate CA with daily Revival will result in at least a 50% reduction in hot flashes compared to placebo.

NCT ID: NCT00244998 Completed - Prostate Cancer Clinical Trials

Fulvestrant in Treating Patients With Advanced Prostate Cancer

Start date: September 2005
Phase: Phase 2
Study type: Interventional

RATIONALE: Estrogen may cause the growth of prostate cancer cells. Hormone therapy using fulvestrant may fight prostate cancer by blocking the use of estrogen by the tumor cells. PURPOSE: This phase II trial is studying how well fulvestrant works in treating patients with advanced prostate cancer.

NCT ID: NCT00244309 Completed - Prostate Cancer Clinical Trials

Study of Tamsulosin and/or Dutasteride to Relieve Urinary Symptoms After Brachytherapy for Localized Prostate Cancer

Start date: November 2005
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether a drug named tamsulosin (Flomax), or another drug named dutasteride (Avodart), or a combination of these two drugs is effective in improving urinary symptoms and decreasing the rate of intermittent self-catheterization after prostate brachytherapy.

NCT ID: NCT00243321 Completed - Clinical trials for Adenocarcinoma of the Prostate

High Dose-Rate Brachytherapy and/or Intensity Modulated External Beam Radiation Therapy for Prostate Cancer

Start date: February 2003
Phase: N/A
Study type: Interventional

The principal objective of this study is to demonstrate that patients can safely receive combined High Dose Rate brachytherapy and Intensity-Modulated Radiation Therapy without experiencing a treatment limiting toxicity.

NCT ID: NCT00243048 Completed - Prostate Cancer Clinical Trials

Isoflavones and Radiation Therapy in Treating Patients With Localized Prostate Cancer

Start date: May 2002
Phase: Phase 2
Study type: Interventional

RATIONALE: Eating a diet high in soy foods may slow the progression of some types of cancer. Isoflavones are compounds found in soy food that may slow the growth of prostate cancer cells and prevent further development of prostate cancer. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving isoflavones together with radiation therapy may be an effective treatment for prostate cancer. PURPOSE: This randomized phase II trial is studying the side effects and how well giving isoflavones together with radiation therapy works in treating patients with localized prostate cancer.

NCT ID: NCT00242918 Completed - Prostate Cancer Clinical Trials

Safety and Effectiveness Study of Docetaxel and ZD1839 Followed by Removal of the Prostate to Treat Prostate Cancer

Start date: May 2003
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine the safety and effectiveness of the combination of docetaxel and ZD1839 on destroying prostate cancer before removal of the prostate.

NCT ID: NCT00242567 Completed - Prostate Cancer Clinical Trials

Study of Zoledronic Acid for Patients With Hormone-sensitive Bone Metastases From Prostate Cancer

Start date: December 2005
Phase: Phase 3
Study type: Interventional

This study aims to determine whether early treatment with zoledronic acid, that is given during the early phase of advanced prostate cancer, will be more efficacious than delayed treatment