Prostate Cancer Clinical Trial
Official title:
Phase I Dose Escalating Study to Evaluate the Safety, Tolerability, Anti-Tumour Activity and Pharmacokinetic and Pharmacodynamic Profiles of Foxy-5 in Patients With Metastatic Breast, Colon or Prostate Cancer
The Wnt proteins belong to a family of proteins that have been demonstrated to play a role
in the formation and dissemination of tumours. The present project focuses on the critical
role of the Wnt-5a protein in the pathobiological processes that lead to metastatic cancer
disease.
WntResearch has identified a formylated 6 amino acid peptide fragment, named Foxy-5, which
mimick the effects of Wnt-5a to impair migration of epithelial cancer cells and thereby
acting anti-metastatic. The aim of the present clinical phase 1 trial is to establish the
recommended dose for a clinical phase 2 study and thereby further develop Foxy-5 as a first
in class anti-metastatic cancer drug. Foxy-5 is designed to inhibit the development of
metastasis by reducing the motility of cancer cells and should thereby increase the survival
rates of patients with solid malignant tumours.
n/a
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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