Prostate Cancer Clinical Trial
Official title:
Proteases in Prostate Cancer Bone Metastasis
RATIONALE: Collecting and storing samples of bone marrow and tissue from patients to test in
the laboratory may help the study of cancer.
PURPOSE: This laboratory study is comparing proteases (enzymes that break down protein) in
patients with prostate cancer that has spread to the bone with patients who do not have
cancer that has spread to the bone.
OBJECTIVES:
- Examine the roles of proteases and protease-associated molecules in bone metastases in
patients with metastatic prostate cancer.
OUTLINE: Patients undergo bone marrow aspiration and core bone biopsies. Tissues are
analyzed by immunohistochemistry methods, in situ hybridization assays, gelatin zymography
and/or Western blot analysis, and gene profiling analysis in order to visualize and
quantitate protease or protease-related levels.
PROJECTED ACCRUAL: A total of 50 patients will be accrued for this study.
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N/A
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