Prostate Cancer Clinical Trial
Official title:
ONE-SHOT - Single Shot Radiotherapy for Localized Prostate Cancer. A Multicenter, Single Arm, Phase I/II Trial
The main objective of the phase I/II trial is to determine the safety and efficacy of a single fraction SBRT at a dose of 19 Gy in patients with localized prostate cancer.
Total dose and dose per fraction play an important role in the curative treatment of prostate
cancer with radiotherapy (RT). Modern image guided external RT allows safe dose escalation of
prostate cancer. There are strong radiobiological and clinical considerations that suggest
that treatment with a small number of large fractions (hypofractionation) may increase the
therapeutic ratio of RT for prostate cancer by increasing the tumor cell killing effect with
relatively less toxic effect on the surrounding late responding normal tissues compared to
conventional fractionation.
The question of how far can the number of fractions with SBRT be reduced is an exciting
research matter with an undoubtful goal, face the challenge of assessing the potential for
cure of prostate cancer patients with a single and unique fraction of high dose irradiation
similar to what is already undertaken with radiosurgery against brain, lung, and liver
targets.
We hypothesize that an ultra-hypofractionated single-dose SBRT employing state of the art of
image-guided RT techniques may be feasible, with a safe toxicity profile and an optimal
long-term tumor control. Hence, a prospective phase I/II clinical trial will be initiated in
prostate cancer patients with a localized disease to validate this treatment schedule as an
alternative to normofractionated/moderate hypofractionated RT schedules to be tested in a
second time in a phase III trial.
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