Pregnancy Clinical Trial
Official title:
Clinical Study of the Effect of Gestational Weight Gain on Composition of Gut Microbiome
A prospective, multicenter, observational cohort study including about 550 mother-infant pairs in Beijing will be conducted to evaluate the association between mothers' gestational weight gain and the gut microbiota of them and their infants.
Purpose To evaluate whether mothers' gestational weight gain is associated with differences
in maternal and their infants gut microbiota characteristics.
Methods and analysis This is a prospective, multicenter, observational cohort study including
about 550 mother-infant pairs from PUMCH and other 3 hospitals in Beijing. After signing
consent form, every participant will bring home a weighting scale for checking and record the
weight every week from they enrolled to a year postpartum. The blood samples, fecal samples,
vaginal swabs and oral swabs of the mothers will be collected at first, second, third
trimester and postpartum 42 days. The infants' fecal samples will be collected at 0~3, 14, 42
days and 3, 6, 9, 12 months after born. Questionnaire for mothers (diet, exercise, antibiotic
and probiotic usage, oral hygiene habits etc.) and their infants (delivery mode, feeding
pattern, antibiotic and probiotic usage etc.), as well as the medical records will be
collected along with the sample collecting. Bio-specimen will be tested by 16S rRNA gene
sequencing. Logistical regression and covariance analysis will be used to determine the
relationships between the demographic data, gestational weight gain and microbiota
composition.
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