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Postoperative Recovery clinical trials

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NCT ID: NCT06347770 Recruiting - Microbiota Clinical Trials

Effect of Probiotics Before Cesarean Section on Postoperative Recovery in Pregnant Women

Start date: November 1, 2023
Phase: N/A
Study type: Interventional

This study aims to evaluate the effect of probiotics 7 days before cesarean section (CS) on postoperative recovery and the change of gut microbiota in pregnant women. Samples were obtained from a total of 80 pregnant individuals, divided into control group and probiotics group. Anal exhaust time and first defecating time were set as the primary outcome of recovery of CS. 16S rRNA amplicon sequencing of the V4 region was analyzed to evaluate the composition of them.

NCT ID: NCT06341049 Recruiting - Clinical trials for Postoperative Recovery

Effect of Three Different Postcesarean Analgesic Techniques on QbsQor-10 Score: Prospective, Randomized Trial

Start date: March 12, 2024
Phase: N/A
Study type: Interventional

The aim of this study is to evaluate the effects of three different postsesarean analgesia techniques, including instillation of local anesthetic into the peritoneum with infiltration into all layers of the anterior abdominal wall, intrathecal morphine injection with local anesthetic, and quadrotus lumborum type 1 block, on the postoperative recovery of women using the ObsQoR-10 score..

NCT ID: NCT06305221 Recruiting - Clinical trials for Postoperative Recovery

Effect of Opioid-free Analgesia and Anesthesia on the Quality of Postoperative Recovery and Nausea Vomit in Patients Receiving Laparoscopic Sleeve Gastrectomy

Start date: March 9, 2024
Phase: N/A
Study type: Interventional

The purpose of the intraoperative use of opioids is to reduce the amount of sedative medication and to ensure effective analgesia. But pain is an unpleasant sensory and emotional experience (a cognitive perception) that cannot occur with sufficient depth of anesthesia (even without opioids). So a more reasonable explanation for analgesia should be anti-nociception and the resulting inhibition of the response to surgical stress. Since multiple mediators are involved in nociceptive pathways, antinociception can also be acquired through multiple mechanisms. However, there is no single ideal harm drug to replace opioids, which often requires two or more drugs to meet clinical needs. While regional block attenuates the stress response to surgery and sympathetic activation because of afferents to block nociceptive stimuli, and has an important role in the implementation of OFA. Combined with the clinical characteristics of the LSG, investigators developed the transverse abdominis fascia block (transversus abdominis plane TAP) in combination with esketamine (esketamine), dexmedetomidine (dexmedetomidine, DEX) of opioid-free anesthesia (opioid free anesthesia, OFA) and the analgesic regimen (TEDOFA), Reduce patient pain scores, nausea and vomiting after LSG based on perfect analgesia and adequate anti-sympathetic response, As well as the other complications, Promote the accelerated postoperative recovery of patients undergoing LSG, And reduce the incidence and severity of postoperative chronic pain.

NCT ID: NCT06244654 Recruiting - Anxiety Clinical Trials

Anxiolytic Effectiveness of Virtual Reality Glasses in Surgery

Start date: January 25, 2024
Phase: N/A
Study type: Interventional

Regional anesthesia allows surgery without affecting the patient's level of consciousness.However, this may cause anxiety in some patients.In previous research, scientists have tried to prevent anxiety with non-pharmacological interventions such as music and cognitive therapies.Virtual reality is thought to offer an immersive experience that can alter the mind's perception of pain. Scientists have found in previous preliminary studies that virtual reality is safe and effective as an adjunct to standard sedative/analgesic protocols for reducing patients' pain and anxiety during endoscopy, colonoscopy, dental treatments, burn dressings, and labor. In this study, it is expected that anxiety scores, postoperative analgesic need and intraoperative sedation need will decrease, recovery quality will improve and patient satisfaction will increase in patients who will undergo upper extremity surgery under regional anesthesia and watch videos through VR glasses.

NCT ID: NCT06145165 Recruiting - Clinical trials for Postoperative Recovery

A Analgesic Study of Adductor Canal &IPACK Block With Liposomal Bupivacaine in Knee Arthroplasty

Start date: December 1, 2023
Phase: Phase 1
Study type: Interventional

To study the effectiveness of ACB and iPACK block with liposomal bupivacaine for postoperative analgesia in patients undergoing knee arthroplasty

NCT ID: NCT05879536 Recruiting - Post Operative Pain Clinical Trials

The Effect of Intravenous Infusion of Tramadol-ondansetron on Recovery After Caesarean Section.

TRON
Start date: May 23, 2023
Phase:
Study type: Observational

It will be a prospective observational cohort study. The investigators will compare post-cesarean section recovery in patients receiving intravenous infusion of tramadol-ondansetron versus epidural catheter with infusion of local anesthetics.

NCT ID: NCT05843383 Recruiting - Clinical trials for Postoperative Complications

Comparison of Ciprofol-based and Propofol-based Total Intravenous Anesthesia on Postoperative Quality of Recovery

Start date: May 16, 2023
Phase: N/A
Study type: Interventional

Ciprofol is a novel 2,6-disubstituted phenol derivatives and is proved have much higher potency and tighter binding toward ɣ-aminobutyric acid type A (GABAA) receptor while maintaining a fast on-set and recovery time compared to propofol. Except lower incidence of hypotension and respiratory depression, it has no injection pain and infusion syndrome compared with propofol. There is no study to investigate overall postoperative functional recovery in patients receiving total intravenous anesthesia (TIVA) using ciprofol yet. However, according to study, early quality of recovery according to QoR-15 score is associated with one-month postoperative complications after elective surgery. Therefore, the purpose of this study is to determine whether there is any difference in the quality of postoperative recovery between ciprofol-based and propofol-based TIVA in elderly patients undergoing gastrointestinal surgery. The QoR-15 questionnaire score, pain, nausea/vomiting, and the frequency of complications are evaluated and compared between the two groups.

NCT ID: NCT05782036 Recruiting - Clinical trials for Postoperative Recovery

Dynamic Characterization of Postoperative Recovery After Cardiac Surgery

Start date: April 1, 2023
Phase:
Study type: Observational

With the improvement of surgical techniques and medical care levels, most cardiac surgery patients have a good prognosis, and the long-term postoperative survival rate of some surgical patients has not significantly differed from that of the general population. While cardiac surgery is traumatic for patients and has a long postoperative recovery cycle, the recovery of patients is equally of concern. Postoperative recovery is a complex concept involving multiple domains, including patients' physiological functions, mental health, and pain, etc. These states will not only continuously change over time, but also the situation of postoperative recovery in patients with different characteristics is very different. Accordingly, the investigators aim to characterize trajectories of patient recovery after cardiac surgery using PROMs. The investigators will conduct a prospective study to characterize trajectories of postoperative recovery in multiple domains after cardiac surgery.

NCT ID: NCT05664386 Recruiting - Anesthesia Clinical Trials

Effect of Ciprofol Infusion for Induction and Maintenance on Hemodynamics and Postoperative Recovery

Start date: April 10, 2023
Phase: Phase 4
Study type: Interventional

To study the Effect of Ciprofol Infusion for Induction and Maintenance of anesthesia on Hemodynamics and Postoperative Recovery in Patients Undergoing Thoracoscopic Lobectomy:a randomized, controlled trial.

NCT ID: NCT05596695 Recruiting - Blood Pressure Clinical Trials

Minimisation of Blood Pressure Variability and Postoperative Nausea and Vomiting

SICK
Start date: October 1, 2022
Phase: N/A
Study type: Interventional

Intraoperative hypotension is associated with postoperative nausea and vomiting (PONV). Even though the exact mechanism linking PONV and hypotension is still unclear, a reduced intestinal tissue perfusion might trigger nausea and vomiting. Still to date only limited data evaluating intraoperative blood pressure and the incidence of PONV after general anesthesia exits. Furthermore, the effect of intraoperative blood pressure variability on the incidence of PONV has not been investigated yet. Therefore, we will test our primary hypothesis that the incidence of PONV during the early (0-2h) postoperative period will be minimized by targeting intraoperative blood pressure variability to a SPB of 120±5mmHg by using a continuous vasopressor infusion in female patients undergoing elective minor to moderate risk non-cardiac surgery.