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Comparison of Two Doses of Carbetocin for Prevention of Uterine Atony, During Elective Cesarean Section

Uterine Atony Clinical Trial

Official title:
Comparison of Two Doses of Carbetocin for Prevention of Uterine Atony During Elective Cesarean Section: a Randomized Controlled Trial

Clinical Trial Summary

The purpose of this study is to evaluate the effectiveness of two doses of carbetocin (50 mcg vs 100 mcg) in preventing uterine atony during elective cesarean section.

Clinical Trial Description

Postpartum hemorrhage is a major cause of mortality and morbidity in the world, and it is most often caused by uterine atony. To prevent this complication, uterotonic medication is used during elective cesarean section.

Carbetocin, a long-acting synthetic analogue of oxytocin, has been used for this purpose for many years. This medication has numerous side effects: hypotension, tachycardia, nausea, vomiting, chest pain, etc. Using a smaller dose of carbetocin might lower the incidence of these side effects, without compromising prevention of uterine atony in a low-risk group of patient. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01630187
Study type Interventional
Source Laval University
Contact
Status Completed
Phase Phase 4
Start date April 2012
Completion date July 2012
View Details
See also
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Completed NCT05027048 - Calcium Chloride for Prevention of Blood Loss During Intrapartum Cesarean Delivery Phase 3
Completed NCT01549223 - Oxytocin And Uterotonic Agent Use For Cesarean Delivery Phase 4