Post-operative Pain Clinical Trial
Official title:
Liposomal Bupivacaine for Total Knee Arthroplasty Postoperative Analgesia
Continuous femoral nerve blocks (CFNB) provide effective pain control to patients undergoing total knee replacement (TKR). However the resulting motor blockade can lead to decreased quadriceps muscle strength and delayed functional recovery.The purpose of this study is to compare the effect of Liposome Bupivacaine infiltration into the knee to CFNB on pain control and functional recovery
This is a prospective, randomized, active controlled study in patients undergoing total knee
replacement. The objective of this study is to compare the efficacy of Liposome Bupivacaine,
in managing postoperative pain, to standard of care CFNB. Following informed consent,
patients will be randomized to one of two groups, Liposome Bupivacaine or active control,
CFNB group.
266 mg Liposome Bupivacaine plus Bupivicaine HCL (150mg) will be administered via local joint
infiltration around the knee joint prior to wound closure. In the control group a CFNB will
be placed for 48hrs prior to surgery. Outcomes measured included pain at rest, movement and
quadriceps muscle strength on the first and second postoperative day.
It is hypothesized that Liposome Bupivacaine will provide effective pain control and improved
preservation of quadriceps muscle strength, in comparison to CFNB.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02489526 -
Evaluate the Analgesic Efficacy and Safety of VVZ-149 Injections for Post-Operative Pain Following Colorectal Surgery
|
Phase 2 | |
| Terminated |
NCT05146453 -
Sternotomies and PectoIntercostal Fascia Blocks in Fast-Track Cardiac Anesthesiology
|
Phase 4 | |
| Completed |
NCT05635916 -
Trial of Liposomal Bupivacaine for TKA
|
Phase 4 | |
| Recruiting |
NCT06028126 -
Superficial Parasternal Intercostal Plane Block in Cardiac Surgery Trial
|
N/A | |
| Not yet recruiting |
NCT03591172 -
Using Three Different Final Irrigants and Showing Their Effects on the Success of Revascularization
|
N/A | |
| Completed |
NCT01686802 -
Post-operative Oral Morphine Versus Ibuprofen
|
Phase 2 | |
| Completed |
NCT01667445 -
Evaluation of the Use of Spinal Epimorph in Total Knee Arthroplasty
|
Phase 4 | |
| Completed |
NCT01444924 -
Transversus Abdominis Plane Blocks for Patients Undergoing Robotic Gynecologic Oncology Surgery
|
Phase 2 | |
| Completed |
NCT00968955 -
Effect of Local Infiltration Analgesia in Total Hip Arthroplasty
|
Phase 4 | |
| Completed |
NCT00830089 -
Trial of a Transversus Abdominis Plane (TAP) Block in Laparoscopic Colorectal Surgery
|
N/A | |
| Terminated |
NCT00875862 -
Shoulder Adhesive Capsulitis and Ambulatory Continuous Interscalene Nerve Blocks
|
Phase 4 | |
| Completed |
NCT00847093 -
LMX-4 for Postoperative Pain Management in Infants and Children Undergoing Penoplasty Surgery
|
Phase 4 | |
| Completed |
NCT00390312 -
Efficacy and Safety of Intranasal Morphine for Pain After Third Molar Extraction
|
Phase 2 | |
| Recruiting |
NCT05278494 -
Dextromethorphan for Treatment of Postoperative Pain
|
N/A | |
| Recruiting |
NCT05973045 -
Investigation of the Effect of Distention Medium Temperature on Image Quality, Hyponatremia Risk, and Post-operative Pain in Operative Hysteroscopy
|
N/A | |
| Not yet recruiting |
NCT04999670 -
Fascial Closure and Post-caesarean Pain
|
N/A | |
| Enrolling by invitation |
NCT04346407 -
Dronabinol for Post-operative Pain After Lumbar Fusion
|
Phase 4 | |
| Completed |
NCT03635515 -
Occurrence of Post-op Pain Following Gentlewave
|
N/A | |
| Terminated |
NCT03201809 -
Comparison of Preoperative Ultrasound Guided Pectoralis Nerve Block Placement Versus Intra-operative Placement: A Prospective Randomized Trial
|
N/A | |
| Completed |
NCT03254056 -
Fascial Closure Techniques Post-Operative Pain Laparoscopy
|
N/A |