Post-operative Pain Clinical Trial
Official title:
Liposomal Bupivacaine for Total Knee Arthroplasty Postoperative Analgesia
Continuous femoral nerve blocks (CFNB) provide effective pain control to patients undergoing total knee replacement (TKR). However the resulting motor blockade can lead to decreased quadriceps muscle strength and delayed functional recovery.The purpose of this study is to compare the effect of Liposome Bupivacaine infiltration into the knee to CFNB on pain control and functional recovery
This is a prospective, randomized, active controlled study in patients undergoing total knee
replacement. The objective of this study is to compare the efficacy of Liposome Bupivacaine,
in managing postoperative pain, to standard of care CFNB. Following informed consent,
patients will be randomized to one of two groups, Liposome Bupivacaine or active control,
CFNB group.
266 mg Liposome Bupivacaine plus Bupivicaine HCL (150mg) will be administered via local joint
infiltration around the knee joint prior to wound closure. In the control group a CFNB will
be placed for 48hrs prior to surgery. Outcomes measured included pain at rest, movement and
quadriceps muscle strength on the first and second postoperative day.
It is hypothesized that Liposome Bupivacaine will provide effective pain control and improved
preservation of quadriceps muscle strength, in comparison to CFNB.
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