Outcome After Laparoscopic Surgery for Peptic Ulcer Perforation

Pneumonia Clinical Trial

Official title:

Whether Peritoneal Irrigation Intra-operatively Effects on the Outcome After Laparoscopic Surgery for Peptic Ulcer Perforation

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05147870
• Other study ID #: 201021
• Status: Completed
• Start date: January 1, 2013
• Est. completion date: August 31, 2021

Study information

• Verified date: November 2021
• Source: Changhua Christian Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Despite advances in laparoscopic surgery for perforated peptic ulcer (PPU), intra-abdominal abscess (IAA) is recognized as one of the commonly reported complications with relation to the extent of infectious abdominal contamination. Herein, the investigators report their experience of laparoscopic surgery for PPU with/without peritoneal irrigation and discuss postoperative outcome. The investigators retrospectively examined the electronic medical records of the patients who underwent laparoscopic surgery for perforated peptic ulcer at a single medical center in Taiwan between January 2013 and August 2021. Retrospectively, the investigators would include those patients with clinical diagnosis of PPU who underwent emergent laparoscopic surgery. The patients with previous abdominal surgery, pathologic confirmed malignant ulcer perforation or concomitant ulcer bleeding were excluded. The investigators focused on post-operative complications and outcome after laparoscopic surgery with or without peritoneal irrigation. This information can be important in improving surgical options with respect to risk and potential benefits in this setting.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 150
• Est. completion date: August 31, 2021
• Est. primary completion date: August 31, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• The patients with clinical diagnosis of PPU underwent laparoscopic repair surgery.

Exclusion Criteria:

• The patients received surgery in an open approach or underwent laparoscopy initially but then intraoperatively converted to laparotomy.

Related Conditions & MeSH terms

• Abdominal Abscess
• Abscess
• Leakage
• Operation Wound; Infection
• Peptic Ulcer
• Peptic Ulcer Perforation
• Pneumonia
• Surgical Wound Infection
• Wound Infection

Intervention

Procedure:
• Peritoneal irrigation
For patients allocated to the irrigation group, peritoneal lavage was performed at the surgeon's discretion based on surgical findings and preference.
• Suction only
In the suction only group, one surgical gauze each was placed in the splenophrenic space and Morison's pouch to soak up any remaining purulent fluid followed by turning the patient into the Trendelenburg position for inspection of the lower abdominal cavity. Any interloop adhesions were carefully divided and the gauze-wiping maneuver was used to soak up the residual peritoneal fluid, and all bowel loops were investigated to the root of the mesentery.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Chang Wei-Jung

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Short-term outcome with wound infection, pneumonia, leakage, and intraabdominal abscess	Complication grading used clavien dindo classification	Through hospitalization, an average of 8 days