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Placebo Effect clinical trials

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NCT ID: NCT06423365 Not yet recruiting - Clinical trials for Cardiovascular Diseases

A Tool to Help Patients With Muscle Symptoms After Taking a Statin Medication.

Start date: July 1, 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to learn if an educational website can help patients make an informed decision and engage in shared decision-making with their healthcare provider regarding cholesterol lowering medication use after they have stopped statin therapy due to self-reported muscle symptoms from taking a statin medication. The main questions the trial aims to answer are: 1. Compared to usual care, are patients who engage with the website after experiencing statin-associated muscle symptoms (SAMS) more likely to retry statin therapy? 2. Compared to usual care, are patients who retry statin therapy after engaging with the website more likely to persist on statin therapy? Researchers will compare people randomized to use the website to those who are receiving usual care to see if statin re-start and persistence rates change. All participants will take baseline questionnaires and receive usual care as they would if they were not in the study (e.g., visit their doctor, get labs drawn, take medication as prescribed). Patients randomized to the website arm will be asked to engage with content in a website which is anticipated to take most patients approximately 30-minutes. Their clinician will then contact them for a follow-up visit as needed.

NCT ID: NCT05004467 Completed - Disability Physical Clinical Trials

Clinical Predictive Effects of Mulligan Treatment in Patients With Chronic Neck Pain

Start date: August 2, 2021
Phase: N/A
Study type: Interventional

The aim of the study is the measurement and comparison of two manual therapy techniques, the Mulligan´s mobilization with movement technique, and de placebo technique, both applicated in patients with subacute neck pain.

NCT ID: NCT04766580 Recruiting - Pain Clinical Trials

Attention and Pain in Children With and Without Attention Deficit and/or Hyperactivity Disorder

ADE
Start date: February 17, 2021
Phase: N/A
Study type: Interventional

In Quebec, there has been an important increase of Attention Deficit Hyperactivity Disorder (ADHD) diagnosis since 2015. ADHD symptoms, related to behavioural and/or concentration difficulties, are very similar to other disorders symptoms, such as anxiety and depression, and have a significant impact on students' academic success and future life. Adults (parent, teacher, coach) expectations towards a child's abilities are consciously or unconsciously perceived by the child, influence his expectations of his own abilities, and thus his academic performance (Pygmalion effect). The child and his entourage's expectations are therefore a major factor to consider, especially in school-age children. According to ADHD studies, some brain areas involved in pain regulation and in attention cognitive abilities develop at a slower rate in children with ADHD than the other children. Considering the deleterious consequences generated by the symptoms of this disorder, the research project aims to better understand the role of expectations in children with ADHD in a medical (pain) and school (attention abilities) context. It also aims to contribute to better understand the role of the brain on the expectations effect and ADHD. In this study, children expectations will be modulated while pain experiments and cognitive task will be realized by children with and without ADHD. Brain measures will also be assessed with advanced techniques. Thus, we hope that the results will help improve intervention strategies in these contexts to ensure better support for children with ADHD, with a distant goal of contributing to the development of stronger tools for differential diagnostics.

NCT ID: NCT04650841 Not yet recruiting - Pain Clinical Trials

The Role of the Opioid System in Placebo Effects on Pain and Social Rejection

Start date: September 1, 2024
Phase: Early Phase 1
Study type: Interventional

The current study probes the involvement of the opioid system in placebo effects on social pain, using the opioid antagonist naloxone. 60 participants who recently experienced an unwanted breakup will experience rejection-related stimuli and receive painful heat and pressure stimuli during fMRI scanning. Participants will be randomized to receive either a naloxone or saline nasal spray, and be informed that the spray is either saline, or an effective pain and negative emotion reducing agent.

NCT ID: NCT04646460 Not yet recruiting - Pain Clinical Trials

Context Interventions: Social Modeling and Initial Treatment Experience

Start date: October 1, 2024
Phase: N/A
Study type: Interventional

In this experiment, the investigators study the brain pathways underlying several promising context interventions that enhance the strength of placebo effects. Specifically, the investigators examine the separate and joint effects of two of the most powerful context interventions: Social modeling-observing someone else being effectively treated-and prior treatment success or failure experiences. Participants will be randomized into 4 groups (Social modeling: observed success vs. observed failure and Conditioning: experienced success vs. experienced failure). The objectives are to investigate the placebo effect on pain relief and aversive image stimuli between and within-subjects. Each group will undergo a behavioral induction phase, fMRI placebo test phase, and an identical 3-month follow up fMRI placebo test phase. Follow-up assessment will provide some of the first evidence on predictors of the durability of placebo and context interventions.

NCT ID: NCT04571827 Completed - Disability Clinical Trials

The Influence of Expectations on Post-needling Soreness and Pain Processing After Dry Needling Treatment

Start date: October 1, 2020
Phase: N/A
Study type: Interventional

The general objective of the study is to determine the effectiveness on local mechanical hypoalgesia, pain intensity, disability and psychological variables of the deep dry needling technique on a latent trigger point of the upper trapezius muscle. The specific objective of the study is to observe the interaction between patient expectations and hypoalgesic effects in patients who will receive the same technique but with different explanations about it before punction and which could influence on the modulation of post-punction pain.

NCT ID: NCT03950999 Recruiting - Healthy Clinical Trials

Experimental Pain Reporting Accuracy and Placebo Response

Start date: August 13, 2017
Phase: N/A
Study type: Interventional

Good clinical care relies on precise evaluation of patients' conditions. Chronic pain and other neurological and psychiatric diagnoses pose challenges because their assessment depends on subjective patient-reported outcome measures (PROs). The investigators have recently developed the Focused Analgesia Selection Task (FAST), a method that allows assessing pain reporting accuracy. Preliminary results suggest that those who more accurately report their pain show diminished placebo response. The underlying mechanisms for this observation cannot be explained by current theories. Therefore, the investigators have conducted a pilot study to further characterize this relation in healthy population.

NCT ID: NCT03694886 Completed - Placebo Effect Clinical Trials

The Effect of Tablet Size on Cognitive Performance Caffeine

CaC
Start date: October 31, 2018
Phase: Phase 4
Study type: Interventional

This study aims to assess if tablet size, due to placebo effect, alters participants' performance on cognitive tests after consuming caffeine. Participants will be randomly assigned to one of four groups: 1) 90 mg caffeine with a 1 mm diameter sucrose pillule; 2) no caffeine with the small sucrose pillule; 3) 90 mg caffeine with a 5 mm sucrose pillule; 4) no caffeine with the large sucrose pillule.

NCT ID: NCT03017534 Completed - Clinical trials for Musculoskeletal Manipulations

Non-Specific Effects of Manual Therapy

Start date: January 2017
Phase: N/A
Study type: Interventional

The mechanism responsible for improvement following manual physical therapy techniques is unknown. Previous studies have indicated both biomechanical and neurophysiologic effects which may be responsible for clinical changes observed. Yet, other studies report clinical changes following sham interventions. Through a mixed-methods design, this study aims to gain more understanding of the social and contextual factors that may be related to the improvement often observed following manual therapy techniques.

NCT ID: NCT02802241 Completed - Clinical trials for Irritable Bowel Syndrome

Effects of Open-label vs Double-blind Treatment in IBS

Start date: June 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate placebo effects and peppermint oil in Irritable Bowel Syndrome.