Exercise Program in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy — WISER-NET  

Physical Activity Clinical Trial

Official title: Women In Steady Exercise Research - Neoadjuvant Exercise Trial

Status Completed

Clinical Trial Summary

The investigators seek to conduct a home based exercise intervention in breast cancer patients whom elect to undergo neoadjuvant chemotherapy. The primary aim of the study is to determine whether breast cancer patients can be enrolled, randomized, retained, and comply with exercise program; and, the feasibility of acquiring, managing and analyzing clinical data.

Clinical Trial Description

Several national and international agencies recommend exercise participation for all persons following a cancer diagnosis. The current evidence suggests that aerobic exercise training is safe during primary adjuvant therapy and improves cardiopulmonary function and patient related outcomes. Cardiopulmonary fitness is highly predictive of overall and cardiovascular specific mortality in women. Specifically, an increase in cardiopulmonary fitness of approximately 10% has been associated with a 19% reduction in risk for CV mortality. This is important as breast cancer patients already present at diagnosis with 31% lower cardiopulmonary fitness levels compared to healthy age-matched women. This enhanced risk for cardiovascular mortality in breast cancer patients is further compounded by cardiotoxic chemotherapy, which causes permanent cardiac damage. Few studies have tested the efficacy of exercise prescriptions that incorporate high intensity aerobic exercise training in cancer patients, especially those receiving chemotherapy. Therefore, the investigators seek to conduct an at home aerobic exercise training intervention in breast cancer patients whom elect to undergo neoadjuvant chemotherapy ;

Related Conditions & MeSH terms

• Breast Neoplasm
• Breast Neoplasms
• Physical Activity

• NCT number: NCT03280836
• Study type: Interventional
• Source: Milton S. Hershey Medical Center
• Status: Completed
• Phase: N/A
• Start date: August 3, 2017
• Completion date: December 21, 2020