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Periodontitis clinical trials

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NCT ID: NCT03340012 Not yet recruiting - Clinical trials for Periodontitis, Aggressive

Clinical and Radiographic Evaluation of Guided Tissue Regeneration With Radiation-sterilized Allogenic Bone Grafts or Xenogenic Grafts for the Treatment of Intrabony Defects in Aggressive Periodontitis

Start date: January 5, 2018
Phase: N/A
Study type: Interventional

The treatment of intrabony defects in patients with aggressive periodontitis remains a challenging procedure and novel therapeutic strategies are sought. The purpose of this study is to compare the clinical and radiographic outcomes of using guided tissue regeneration (GTR) with radiation-sterilized allogenic bone grafts (material prepared in the Central Tissue Bank in Warsaw, Poland) versus guided tissue regeneration with xenogenic grafts (Bio-Oss®, Geistlich Biomaterials, Princeton, New Jersey, United States) in the treatment of localized intrabony defects in patients with aggressive periodontitis.

NCT ID: NCT03320135 Completed - Clinical trials for Generalized Aggressive Periodontitis

EMD for Treatment of Proximal Class-II Furcation Involvements

OFD
Start date: October 20, 2017
Phase: N/A
Study type: Interventional

The aim of the present study is to evaluate the clinical response of proximal furcations treated with enamel matrix derivative proteins (EMD).

NCT ID: NCT03311906 Completed - Periodontitis Clinical Trials

Evaluation of the Efficacy of 0.8% Hyaluronic Acid Gel

Start date: February 15, 2017
Phase: Phase 4
Study type: Interventional

assess the clinical and laboratory effects of the local and sub gingival application of a 0.8% hyaluronic acid gel (GENGIGEL®) as an adjunct to scaling and root planning (SRP) in chronic moderate to severe periodontitis patients as indicated by expression of Human Beta Definsin-2 (HBD2) in gingival crevicular fluid (GCF).

NCT ID: NCT03311243 Completed - Clinical trials for Chronic Periodontitis

Periodontal Therapy in Thalassemia Major Patients

Start date: January 11, 2016
Phase: N/A
Study type: Interventional

The study aims to evaluate the effect of local non surgical periodontal therapy on the systemic pro-inflammatory markers in the β-thalassemia (TM-β) patients with chronic periodontitis and systemically healthy demographically matched controls with chronic periodontitis. Both groups will receive non surgical periodontal therapy.

NCT ID: NCT03308019 Completed - Smoking Clinical Trials

Adjunct Photodynamic Therapy in Chronic Periodontitis Among Cigarette-smokers.

Start date: February 16, 2016
Phase: N/A
Study type: Interventional

This study evaluates the efficacy of scaling and root planing with and without adjunct antimicrobial photodynamic therapy (aPDT) in the treatment of chronic periodontitis (CP) among cigarette-smokers and never-smokers.

NCT ID: NCT03297749 Active, not recruiting - Metabolic Syndrome Clinical Trials

Genetic Variants and Oxidative Stress as Links Between Periodontitis and Metabolic Syndrome

Start date: July 1, 2015
Phase: N/A
Study type: Observational

The aim of this study is to investigate the systemic impact of periodontitis in patients with Metabolic Syndrome, by assessing measures of sub-clinical atherosclerosis and cardiovascular risk, microbial factors and host genetic variants, and to study the possible effect of mediators of inflammation and oxidative stress as links between the two conditions.

NCT ID: NCT03295461 Completed - Periodontitis Clinical Trials

Emblica Officinalis Irrigation in Periodontitis

Start date: March 2013
Phase: N/A
Study type: Interventional

E. officinalis fruit possesses both the antimicrobial and anti-inflammatory activities that may prove to be useful against several periodontal diseases with the advantage that it is devoid of side effects associated with synthetic drugs. After the careful search of literature, none of the studies have reported the effect of local drug delivery of E. officinalis preparations on chronic periodontitis.The present study is designed with the aim of assessing the effectiveness of Emblica officinalis extract formulations as a potential adjunctive therapeutic strategy in the management of chronic periodontititis

NCT ID: NCT03288467 Completed - Clinical trials for Apical Periodontitis

Effect of Sodium Hypochlorite Concentration on Success of Non-surgical Root Canal Treatment

Start date: November 6, 2016
Phase: N/A
Study type: Interventional

.There is no general agreement regarding the optimal concentration of sodium hypochlorite to be used in endodontic treatment.Therefore, this study aims to evaluate the effect of sodium hypochlorite concentration on the success of primary root canal treatment. The study population comprised of patients requiring primary root canal treatment following the diagnosis of pulpal necrosis with chronic apical periodontitis in mature mandibular first and second molars.Patients were randomly allocated in either High concentration or Low concentration group.

NCT ID: NCT03278054 Completed - Clinical trials for Apical Periodontitis

Effect of Different Instrumentation Technique on Endodontic Outcome

Start date: May 1, 2015
Phase: N/A
Study type: Interventional

Aim: To evaluate and compare the outcome of primary endodontic treatment following use of different instrumentation techniques. Materials and methods: Study subjects were recruited from the pool of patients referred for the non-surgical root canal treatment in the Department of Conservative Dentistry & Endodontics at PGIDS, Rohtak (Haryana). The study population comprised of patients requiring primary root canal treatment following the diagnosis of pulpal necrosis with chronic apical periodontitis in mature mandibular first and second molars. Subjects were allocated to one of the three study groups: manual instrumentation, ProTaper instrumentation and Hybrid instrumentation.

NCT ID: NCT03277404 Completed - Clinical trials for Apical Periodontitis

Effect of Smear Layer on Endodontic Outcome

Start date: May 7, 2015
Phase: N/A
Study type: Interventional

This study evaluated the effect of removal of smear layer on the success of primary root canal treatment.Patients requiring primary root canal treatment in mature mandibular first and second molars were allocated to either smear layer positive group and smear layer negative group.