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Periodontitis clinical trials

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NCT ID: NCT06326073 Completed - Smoking Clinical Trials

Interaction Between Smoking, GCF Periostin, IL17A, IL17E and Non-surgical Periodontal Therapy

Start date: July 1, 2019
Phase: N/A
Study type: Interventional

It was aimed to evaluate the changes in the levels of Periostin, IL-17A and IL-17E cytokines in the gingival crevicular fluid (GCF) of periodontitis patients which non-surgical (Phase I) periodontal treatment applied to and their interactions with smoking. The study included systemic healthy smokers(SP)(n:11) and non-smokers(P)(n:11) with periodontitis, smokers (SS)(n:11) and non-smokers(S)(n:11) with periodontal healthy individuals Phase I periodontal treatment was applied to the groups with periodontitis. Before treatment (day 0), clinical measurements evaluating periodontal status were recorded and GCF samples were collected. GCF samples were collected from the same tooth regions on the 15th and 30th days after treatment and clinical measurements were repeated. GCF Periostin, IL-17A and IL-17E levels were determined by ELISA method. All data were evaluated statistically.

NCT ID: NCT06309797 Completed - Periodontitis Clinical Trials

Effects of Interdental Brush Dipped in 0.2% Hyaluronic Acid Gel on Periodontitis

Start date: May 2, 2023
Phase: N/A
Study type: Interventional

This study aimed to compare the effects of using an interdental brush dipped in 0.2% HA gel with those of using a regular interdental brush on clinical periodontal parameters following SRP among patients with periodontitis.

NCT ID: NCT06306937 Completed - Clinical trials for Periodontal Diseases

Serum Levels of Vitamin D and IL8 in Patients With Periodontitis

Start date: September 1, 2022
Phase:
Study type: Observational

We evaluated vitamin D and IL8 levels in the serum of patients with periodontitis as well as the healthy controls to correlate their levels with the degree of periodontitis.

NCT ID: NCT06295666 Completed - Periodontitis Clinical Trials

Gingival Crevicular Fluid (GCF) Bactericidal Permeability Protein (BPI) and Interleukin (IL)-1 Beta

Start date: February 19, 2019
Phase:
Study type: Observational

Objective: The aim of this study is to determine the amounts of BPI (Bactericidal permeability protein) and interleukin-1beta (IL-1β) in gingival fluid samples obtained from individuals with periodontally healthy and periodontal disease, to compare these amounts between study groups, and to evaluate their relationship with clinical parameters. In cases where clinical parameters increase, IL-1β amounts also increase significantly. The amount of IL-1β in individuals with periodontal disease is significantly higher compared to healthy individuals. There is positive correlation between BPI and clinical parameters. The amount of BPI in individuals with periodontal disease is significantly higher than in healthy individuals. More studies are needed to better understand the importance and therapeutic effect of BPI in periodontitis

NCT ID: NCT06291623 Completed - Clinical trials for Bacterial Viability of Necrotic Pulp With Asymptomatic Apical Periodontitis

Molecular Analysis of Intracanal Microbes After Chemomechanical Procedure and Root Canal Medication: Clinical Study

Start date: May 3, 2022
Phase: Phase 1
Study type: Interventional

This study aimed to evaluate clinically the intracanal microbes at molecular level after using established root canal medicament Calcium hydroxide and potential root canal medicament Glycyrrhizin.and Decontamination Analysis of Controls samples.

NCT ID: NCT06291454 Completed - Clinical trials for Periodontal Diseases

GCF Levels of Chemokines in Periodontitis

Start date: January 1, 2023
Phase:
Study type: Observational [Patient Registry]

This study aimed to determine CCL19/MIP3beta(β) and CCL20/MIP3alpha(α) in the gingival crevicular fluid (GCF) of the patients with different periodontitis phenotypes. A total of 72 individuals, 24 with Stage III Grade B periodontitis (Group 1), 24 with Stage III Grade C periodontitis (Group 2), and 24 periodontally healthy (control group) (Group 3), were included in the study. GCF and clinical periodontal parameters were obtained at baseline. MIP3β and MIP3α levels in GCF were determined by ELISA.

NCT ID: NCT06287424 Completed - Periodontitis Clinical Trials

The Efficacy Of AGE On Periodontitis

Start date: April 4, 2021
Phase: N/A
Study type: Interventional

The objective of this study is to assess the long-term efficacy of "AGE among on deep periodontal pockets by different doses of "AGE" for a period of 18 months.

NCT ID: NCT06255470 Completed - Periodontitis Clinical Trials

Effect of Periodontal Treatment on Salivary and Serum Biomarkers in Periodontitis

Start date: September 1, 2022
Phase: N/A
Study type: Interventional

The present study aimed to determine the effect of non-surgical periodontal treatment on serum and salivary SIRT-1, MMP-9, and T-SOD levels in periodontitis stage III grade B (P-III-B) and C (P-III-C) patients. 17 periodontally healthy, 16 P-III-B and 16 P-III-C subjects were enrolled. At baseline, serum and saliva samples were collected and the whole mouth clinical periodontal parameters were recorded. Periodontitis patients received non-surgical periodontal treatment. Clinical parameters were re-measured and samples were re-collected at 3 months after treatment. Serum and salivary SIRT-1, MMP-9, and T-SOD levels were analyzed by ELISA. Data were analyzed using appropriate statistical tests.

NCT ID: NCT06254118 Completed - Clinical trials for Chronic Periodontitis

Treatment of Periodontitis in Menopausal Patients

Start date: January 22, 2020
Phase: Phase 4
Study type: Interventional

The goal of this clinical trial is to compare the effectiveness of polyunsaturated fatty acids (PUFAs) [omega-3] as an adjunctive treatment to scaling and root planing for menopausal women with periodontitis versus scaling and root alone as a non- surgical treatment . . The main question it aims to answer is: • to investigate the effect of systemic administration of Omega-3 fatty acids in addition to SRP on clinical periodontal parameters and GCF levels of osteocalcin and AST in menopausal women. Participants will given * a soft gelatin capsules containing PUFAs to be consumed directly once daily for 12 months along with non-surgical treatment (group2) ** a soft gelatin capsules containing olive oil to be consumed directly once daily for 12 months along with non-surgical treatment (group1) Researchers will compare group 1 to group 2 to see if PUFAs has an effect on clinical periodontal parameters and GCF levels of osteocalcin and AST in menopausal women. .

NCT ID: NCT06253988 Completed - Clinical trials for Periodontal Diseases

Effect of Probiotics on Periodontitis Stage III Grade C Molar-incisor Pattern

RCT
Start date: January 1, 2023
Phase: Phase 3
Study type: Interventional

the research highlight the effectiveness of probiotics as adjuncts to SRP in the treatment of periodontitis stage III grade C molar-incisor pattern