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Periodontal Health clinical trials

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NCT ID: NCT06255470 Completed - Periodontitis Clinical Trials

Effect of Periodontal Treatment on Salivary and Serum Biomarkers in Periodontitis

Start date: September 1, 2022
Phase: N/A
Study type: Interventional

The present study aimed to determine the effect of non-surgical periodontal treatment on serum and salivary SIRT-1, MMP-9, and T-SOD levels in periodontitis stage III grade B (P-III-B) and C (P-III-C) patients. 17 periodontally healthy, 16 P-III-B and 16 P-III-C subjects were enrolled. At baseline, serum and saliva samples were collected and the whole mouth clinical periodontal parameters were recorded. Periodontitis patients received non-surgical periodontal treatment. Clinical parameters were re-measured and samples were re-collected at 3 months after treatment. Serum and salivary SIRT-1, MMP-9, and T-SOD levels were analyzed by ELISA. Data were analyzed using appropriate statistical tests.

NCT ID: NCT06223477 Recruiting - Periodontal Health Clinical Trials

Effects of Platelet-rich Fibrin and Vitamin Dꝫ Injections on the Periodontal Health

Start date: May 11, 2023
Phase: N/A
Study type: Interventional

The study aims to evaluate the effect of using PRF and vitamin Dꝫ injections on periodontal health and parameters and compare them when used to facilitate orthodontic treatment.

NCT ID: NCT06130189 Recruiting - Diet Habit Clinical Trials

Nutrition, Physical Activity, Mediterranean Diet Adherence, and Children's Oral Health

Start date: October 17, 2023
Phase:
Study type: Observational

The main risk factors for dental caries are inadequate oral hygiene practices, cariogenic bacteria, and cariogenic diet. Among these factors, diet has a different dual relationship with dental caries. Dietary habits have the potential to be a risk factor for dental caries impaired oral and dental health can also lead to deficiencies in dietary intake. Studies have shown that there is a decrease in gum and periodontal diseases in the adult age group with a diet compatible with the Mediterranean diet. This cross-sectional study aims to examine the relationship between a diet compatible with the Mediterranean Diet and dental caries and gum health status in children. We hypothesize that children will have better gum health and less tooth decay with a diet compatible with the Mediterranean diet.

NCT ID: NCT06110221 Completed - Periodontitis Clinical Trials

Activin-A and Interleukin-1β Levels in Periodontitis

Start date: March 22, 2019
Phase:
Study type: Observational [Patient Registry]

Activin-A belongs to the transforming growth factor-beta superfamily and is a multifunctional cytokine that plays a role in inflammation, immune response, tissue repair and regeneration. Proinflammatory cytokine interleukin-1beta (IL-1β) can increase Activin-A expression in various cell types. This study aims to evaluate gingival crevicular fluid (GCF) and salivary Activin-A and IL-β levels in stage III periodontitis. Seventy-five systemically healthy and non-smoker volunteers consisting of 23 stage III periodontitis, 26 gingivitis and 26 periodontally healthy were enrolled. Full-mouth clinical periodontal indices were recorded, unstimulated whole saliva and GCF samples were obtained, Activin-A and IL-1β total amounts were determined by enzyme-linked immunosorbent assay. Statistical comparisons were performed using non-parametric tests.

NCT ID: NCT05949073 Recruiting - Gingival Recession Clinical Trials

The Impact of Retraction Cords on the Gingival Margin Level.

Start date: July 25, 2023
Phase: N/A
Study type: Interventional

The purpose of this study is to examine the relationship between placing specific retraction cord for different periods of time and the post-operative gingival margin level in humans. Determining the amount of immediate reversible and delayed irreversible gingival recession (vertical gingival retraction) that might happen after placing a retraction cord around a natural tooth in healthy humans. It also aims to investigate the impact of mechanical and chemo-mechanical gingival retraction on periodontal health.

NCT ID: NCT05563532 Completed - Dental Anxiety Clinical Trials

Dental Anxiety and Periodontal Health

Start date: December 1, 2019
Phase:
Study type: Observational

Mothers usually have the primary role in bringing up children and developing health-related behaviors. The aim of this study was to determine the effect of mothers' dental anxiety and oral hygiene on the dental anxiety and periodontal health of their children. The study included 280 randomly selected children, aged 4-12 years, who came to the dentist for the first time and their mothers. Demographic and oral hygiene information of the mothers was collected through a questionaire. Dental anxiety of the mothers and children was assessed using the Modified Dental Anxiety Scale (MDAS) and the Venham Picture Test (VPT), respectively.

NCT ID: NCT05395455 Completed - Periodontitis Clinical Trials

Gingival Crevicular Fluid, Salivary, and Serum Biomarkers Levels in Periodontal Treatment

Start date: November 12, 2018
Phase: N/A
Study type: Interventional

The present study aimed to assess the effect of non-surgical periodontal treatment on gingival crevicular fluid (GCF), saliva, and serum IL-26, IL-6, and IL-10 levels in stage III grade B periodontitis (SIII-GB-P) and C periodontitis (SIII-GC-P) patients. 25 periodontally healthy, 25 SIII-GB-P, and 25 SIII-GC-P participants were enrolled. At baseline, GCF, saliva, and serum samples were collected and the whole mouth clinical periodontal parameters were recorded. Periodontitis patients received non-surgical periodontal treatment (NSPT). Clinical parameters and samples were re-collected at 1 and 3 months after NSPT. GCF, saliva, and serum IL-26, IL-6, and IL-10 were analyzed by ELISA. Data were analyzed using appropriate statistical tests.

NCT ID: NCT05005923 Completed - Periodontitis Clinical Trials

Effect of Periodontal Therapy on Biomarkers in Periodontitis

Start date: January 23, 2019
Phase: N/A
Study type: Interventional

The present study aimed to assess the effect of non-surgical periodontal treatment on serum and salivary MMP-8, MAF, MIP-1α, M-CSF, and IL34 levels in periodontitis stage III grade B (P-III-B) and C (P-III-C) patients. 20 periodontally healthy, 20 P-III-B and 25 P-III-C participants were enrolled. At baseline, serum and saliva samples were collected and the whole mouth clinical periodontal parameters were recorded. Periodontitis patients received non-surgical periodontal treatment. Clinical parameters were re-measured and samples were re-collected at 1 and 3 months after treatment. Serum and salivary MMP-8, MAF, MIP-1α, M-CSF, and IL34 levels were analyzed by ELISA. Data were analyzed using appropriate statistical tests.

NCT ID: NCT04634201 Recruiting - Gingivitis Clinical Trials

Effect of Probiotics on the Periodontal Status of Orthodontic Patients

POP
Start date: March 23, 2022
Phase: N/A
Study type: Interventional

Gingival inflammation (gingivitis) is commonly reported in teenagers with fixed orthodontic devices (FOD). Indeed, FODs promote the accumulation of plaque and interfere with the efficacy of tooth brushing. According to in vitro and in vivo studies, the administration of oral probiotic bacteria including Lactobacillus reuteri may reduce the number of periodontal pathogens in saliva and dental plaque. A recent systematic review shows a positive effect of probiotics in addition to tooth brushing in the treatment of periodontitis. However, there is insufficient data regarding the effect of probiotics in the prevention of gum diseases. The aim of this double-blind randomized placebo-controlled study is to assess the effect of probiotics, in addition to dental brushing, on gum inflammation and the composition of the oral microbiota in teenagers with fixed orthodontic appliances

NCT ID: NCT04509843 Recruiting - Periodontal Health Clinical Trials

Impact of Socioeconomic Status and Oral Hygiene Practice on Periodontal Health of Egyptian Adults

Start date: September 1, 2020
Phase:
Study type: Observational [Patient Registry]

evaluation the relationship between the socioeconomic status and periodontal health of Egyptian adults.