Periodontal Diseases Clinical Trial
Official title:
The Effect of Low-level Laser Therapy on Levels of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor 1 in Gingival Crevicular Fluid of Stage 3-4, Grade C Periodontitis Patients Received Non-surgical Periodontal Treatment.
The present study aimed to investigate the effects of low-level laser therapy (LLLT) as an adjunct to non-surgical periodontal treatment (NSPT) on the plasminogen-activating system in Stage 3-4, Grade C periodontitis patients.
Limited data is available regarding the effects of various periodontal treatment protocols on GCF t-PA and PAI-1 levels, and the extent to which LLLT in conjunction with NSPT affects these levels in patients with Stage 3-4, Grade C periodontitis is unknown. Therefore, this study measured standard clinical outcomes and GCF t-PA and PAI-1 levels in patients with Stage 3-4 Grade, C periodontitis in order to assess the use of LLLT as an adjunct to standard NSPT. This split-mouth study was conducted with 15 Stage 3-4, Grade C periodontitis patients and 15 healthy individuals matched for age and sex. Participants were grouped as follows: Periodontitis/NSPT (Sham); Periodontitis/NSPT+LLLT (LLLT); Periodontally Healthy (Control). LLLT was applied following NSPT and again on post-treatment Days 2 and 7. Clinical parameters were recorded at baseline (i.e. before NSPT) and on Day 30. Gingival crevicular fluid (GCF) samples were collected at baseline and during follow-up visits on Days 7, 14 and 30. GCF t-PA and PAI-1 levels were measured with ELISA. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04712630 -
Non-Incised Papillae Surgical Approach (NIPSA) With and Without Graft
|
N/A | |
| Recruiting |
NCT03997552 -
NIPSA Versus Marginal Approach by Palatal Incision and MIST in Periodontal Regeneration
|
N/A | |
| Completed |
NCT04478864 -
Knowledge, Practice and State of Periodontal Health
|
||
| Completed |
NCT03507868 -
YKL-40 and IL-6 Levels in Periodontal Disease
|
||
| Completed |
NCT05720481 -
Impact of Periodontal Treatment on Growth Differentiation Factor-15 Levels
|
N/A | |
| Recruiting |
NCT06052150 -
Oral Health In Cirrhosis of the Liver (ORACLE)
|
||
| Recruiting |
NCT06025955 -
Evaluation of Outcomes of Minimally Invasive Non- Surgical Versus Surgical Therapy in Furcation Involvement.
|
N/A | |
| Recruiting |
NCT03510702 -
SCREENING OF EPIGENETIC BIOMARKERS (miRNAs) IN THE GINGIVAL SULCUS
|
||
| Completed |
NCT05631600 -
Manuka Honey as an Adjunct to Non-surgical Periodontal Therapy: Clinical Study
|
Phase 2/Phase 3 | |
| Active, not recruiting |
NCT05068778 -
Development of an AI App to Improve Compliance in Periodontal Maintenance Patients
|
||
| Not yet recruiting |
NCT05178563 -
Mechanisms of Acute Inflammation Following Periodontal Treatment
|
N/A | |
| Recruiting |
NCT06224699 -
Toothpaste With Sodium Carbonate in Patients With Gingivitis
|
N/A | |
| Recruiting |
NCT06086821 -
Clinical Relevance of Different Time of Periodontal Re-evaluation
|
N/A | |
| Not yet recruiting |
NCT05721313 -
Vital Root Amputation in Molars With Advanced Periodontal Furcation Involvement: a Preliminary Study
|
N/A | |
| Completed |
NCT06040944 -
Antipsychotic Induced Hyperprolactinemaia as Risk Factor for Periodontitis in Schizophrenic Patients
|
||
| Completed |
NCT06306937 -
Serum Levels of Vitamin D and IL8 in Patients With Periodontitis
|
||
| Recruiting |
NCT04669717 -
Antibiotics as Adjuncts to Periodontal Therapy:Pharmacokinetic Considerations and Dosing Strategies
|
Phase 4 | |
| Completed |
NCT05576142 -
Oral Findings in Pediatric Patients With Allergic Rhinitis and/or Asthma
|
||
| Completed |
NCT04017078 -
Assessment of Carotid Artery Calcifications
|
||
| Completed |
NCT03694496 -
The Effectiveness of an Oral Health Education Programme of Adolescents in Hong Kong
|
N/A |