Oral and Systemic aMMP-8 in Periodontal Disease

Periodontal Diseases Clinical Trial

Official title:

Local And Systemic Levels of aMMP-8 in Gingivitis and Stage 3 Periodontitis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04268381
• Other study ID #: 20-2T/39
• Status: Completed
• Start date: January 20, 2020
• Est. completion date: March 20, 2020

Study information

• Verified date: July 2020
• Source: Aydin Adnan Menderes University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Periodontal disease is an inflammatory process that can result in tooth loss and also is considered a modifying factor for systemic health. Matrix metalloproteinase (MMP)-8 is the major collagenase of periodontal tissue breakdown. The aim of the present study is to analyze active (aMMP-8) levels in gingival crevicular fluid (GCF), saliva and serum in the context of new criteria of gingivitis and stage 3 grade C periodontitis.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 83
• Est. completion date: March 20, 2020
• Est. primary completion date: March 20, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 25 Years to 50 Years

Eligibility

Inclusion Criteria:

• systemically healthy and non-smoker individuals aged 25 to 50 years

• having =20 teeth present (except third molars)

• individuals with periodontally healthy, gingivitis and stage 3 periodontitis diagnoses

Exclusion Criteria:

• having any systemic disease

• smoking

• pregnancy or lactation

• using antibiotic or any anti-inflammatory drug or any periodontal treatment within the past 6 months.

Related Conditions & MeSH terms

• Inflammation
• Periodontal Diseases
• Periodontal Inflammation

Intervention

Other:
• Biochemical analysis
aMMP-8 is measured by immunofluorometric assay (IFMA).

Locations

Country	Name	City	State
Turkey	Aydin Adnan Menderes University	Aydin

Sponsors (2)

Lead Sponsor	Collaborator
Aydin Adnan Menderes University	Giresun University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Oral (GCF and saliva) and serum levels of aMMP-8 in periodontitis and gingivitis	aMMP-8 levels	through study completion, an average of 4 months