The Effect of Periodontal Treatment on Psoriasis

Periodontal Diseases Clinical Trial

Official title:

Effects of Non-surgical Periodontal Therapy on Inflammatory Markers of Psoriasis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03939936
• Other study ID #: 17-KAEK-44
• Status: Completed
• Phase: N/A
• Start date: May 1, 2017
• Est. completion date: February 15, 2018

Study information

• Verified date: May 2019
• Source: Tokat Gaziosmanpasa University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

There is a relationship between psoriasis and periodontal disease. This relationship may be double-sided.

Description:

The aim of this randomized controlled clinical study was to determine the effect of non-surgical mechanical periodontal treatment on psoriasis. The study population consisted of 92 periodontitis patients with psoriasis who had untreated periodontal disease. Two randomized groups were formed from these patients. Immediate periodontal treatment (test group, n = 46) and delayed periodontal treatment (control group, n = 46). Clinical periodontal measures, saliva interleukin 2, interleukin 6 and secretory immunoglobulin A levels and PASI scores were performed at baseline and 8th week in control and test group.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 92
• Est. completion date: February 15, 2018
• Est. primary completion date: January 30, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• the presence at least 20 remaining teeth,

• the presence of Stage I or Stage II Periodontitis,

• the presence of diagnosed psoriasis.

Exclusion Criteria:

• patients who had the immune-inflammatory disease and require antibiotic prophylaxis,

• patients who received periodontal treatment prior to 6 months,

• women who were breastfeeding or pregnant,

• patients using medicines such as antibiotics, anti-inflammatory drugs, immune-suppressants.

Related Conditions & MeSH terms

• Periodontal Diseases
• Psoriasis

Intervention

Other:
• Psoriatic measurements
Psoriasis Area and Severity Index (PASI) was performed baseline and after 8 weeks. Saliva samples were taken from patients for the evaluation of proinflammatory cytokine baseline and after 8 weeks.
• Non-surgical periodontal treatment
Non-surgical periodontal treatment was performed baseline and after 8 weeks. Saliva samples were taken from patients for the evaluation of proinflammatory cytokine baseline and after 8 weeks.
• saliva samples
Saliva samples were taken from patients for the evaluation of proinflammatory cytokine baseline and after 8 weeks.

Locations

Country	Name	City	State
Turkey	Gaziosmanpasa University	Tokat

Sponsors (1)

Lead Sponsor	Collaborator
Ozge Gokturk

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Proinflammatory cytokines	The changes in proinflammatory cytokines levels within 8 weeks. Higher values represent a worse outcome. The decrease in proinflammatory cytokines levels is expected after periodontal treatment.	Baseline and after 8 weeks
Secondary	Gingival index	The changes in gingival index level after periodontal treatment. Gingival index was measured for determining the severity of disease and clinical outcome. Higher values represent a worse outcome. After periodontal treatment, a reduction in gingival index value is expected.	Baseline and after 8 weeks
Secondary	PASI index	The changes in PASI index level after periodontal treatment. PASI index was measured for determining the severity of psoriasis disease. Higher values represent a worse outcome. After periodontal treatment, a reduction in PASI index value is expected.	Baseline and after 8 weeks