YKL-40 and IL-6 Levels in Periodontal Disease

Periodontal Diseases Clinical Trial

Official title:

Effect of Non-Surgical Periodontal Therapy on Salivary and Gingival Crevicular Fluid YKL-40 and IL-6 Levels in Chronic Periodontitis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03507868
• Other study ID #: 2016/1003
• Status: Completed
• First received: April 16, 2018
• Last updated: April 16, 2018
• Start date: September 2016
• Est. completion date: January 2018

Study information

• Verified date: April 2018
• Source: Adnan Menderes University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The primer aim of the study was to investigate saliva and gingival crevicular fluid (GCF) YKL-40 and also interleukin-6 (IL-6) levels in chronic periodontitis pathogenesis.

Description:

This study consisted of two groups: 26 periodontally healthy individuals and 26 generalized chronic periodontitis patients. Chronic periodontitis patients were received nonsurgical periodontal treatment. Clinical measurements were recorded, saliva and GCF samples were obtained before and at first and third months after periodontal therapy. Levels of YKL-40 and IL-6 in saliva and GCF were analyzed by enzyme-linked immunosorbent assay.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 52
• Est. completion date: January 2018
• Est. primary completion date: April 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 26 Years to 49 Years

Eligibility

Inclusion Criteria:

Group 1 Inclusion Criteria:

• No bone and attachment loss,

• GI=0, PPD=3mm, CAL=3mm

• Systematically healthy patients

Group 2 Inclusion Criteria:

• GI>1, PPD=5mm, CAL=5mm with alveolar bone loss radiographically.

• Systematically healthy patients

Exclusion Criteria:

• Aggressive Periodontitis,

• Patients with any other systemic diseases,

• Pregnant women and those in the lactation period,

• Patients with smoking habit and taking medication

• Patients received periodontal therapy in last 6 month

Related Conditions & MeSH terms

• Gingival Diseases
• Periodontal Diseases

Intervention

Procedure:
• Nonsurgical periodontal therapy
Nonsurgical periodontal therapy includes oral hygiene education and scaling and root planning approaches to eliminate microbial dental plaque that is the primary etiology of periodontal diseases.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Zeynep Pinar KELES

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	YKL-40 levels	changes in YKL-40 levels after periodontal therapy	at first and third month after therapy
Secondary	IL-6 levels	changes in IL-6 levels after periodontal therapy	at first and third month after therapy