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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT03507868
Other study ID # 2016/1003
Secondary ID
Status Completed
Phase
First received April 16, 2018
Last updated April 16, 2018
Start date September 2016
Est. completion date January 2018

Study information

Verified date April 2018
Source Adnan Menderes University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The primer aim of the study was to investigate saliva and gingival crevicular fluid (GCF) YKL-40 and also interleukin-6 (IL-6) levels in chronic periodontitis pathogenesis.


Description:

This study consisted of two groups: 26 periodontally healthy individuals and 26 generalized chronic periodontitis patients. Chronic periodontitis patients were received nonsurgical periodontal treatment. Clinical measurements were recorded, saliva and GCF samples were obtained before and at first and third months after periodontal therapy. Levels of YKL-40 and IL-6 in saliva and GCF were analyzed by enzyme-linked immunosorbent assay.


Recruitment information / eligibility

Status Completed
Enrollment 52
Est. completion date January 2018
Est. primary completion date April 2017
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 26 Years to 49 Years
Eligibility Inclusion Criteria:

Group 1 Inclusion Criteria:

- No bone and attachment loss,

- GI=0, PPD=3mm, CAL=3mm

- Systematically healthy patients

Group 2 Inclusion Criteria:

- GI>1, PPD=5mm, CAL=5mm with alveolar bone loss radiographically.

- Systematically healthy patients

Exclusion Criteria:

- Aggressive Periodontitis,

- Patients with any other systemic diseases,

- Pregnant women and those in the lactation period,

- Patients with smoking habit and taking medication

- Patients received periodontal therapy in last 6 month

Study Design


Related Conditions & MeSH terms


Intervention

Procedure:
Nonsurgical periodontal therapy
Nonsurgical periodontal therapy includes oral hygiene education and scaling and root planning approaches to eliminate microbial dental plaque that is the primary etiology of periodontal diseases.

Locations

Country Name City State
n/a

Sponsors (1)

Lead Sponsor Collaborator
Zeynep Pinar KELES

Outcome

Type Measure Description Time frame Safety issue
Primary YKL-40 levels changes in YKL-40 levels after periodontal therapy at first and third month after therapy
Secondary IL-6 levels changes in IL-6 levels after periodontal therapy at first and third month after therapy
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