Periodontal Disease Clinical Trial
Official title:
Effects of Periodontal Pathogens, Porphyromonas Gingivalis and Tannerella Forsythensis, on Cytokine Production From Human Monocyte-Derived Dendritic Cells.
Verified date | May 2003 |
Source | National Taiwan University Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | Taiwan: Department of Health |
Study type | Observational |
Periodontitis develops due to subgingival infection with specific microbial pathogen from dental plaque. The bacteria can activate immunoinflammatory mechanisms within the local periodontal tissues that lead to destruction of collagen and alveolar bone. Human gingiva contains Langerhans and connective tissue dendritic cells. Signals from periodontal pathogen can induce dendritic cells to maturation,rapidly increasing surface expression of MHC class II, costimulatory molecules, and secrete proinflammatory cytokines to regulate adaptive T cell immune response. Studies on cytokines have led to controversy about different T cell subsets associated with the progression of periodontitis. Seymour proposed that susceptibility to periodontal disease progression involve a predominantly Th2 response while Ebersole speculated that Th2 cells providing protective function. It is possible that a given pathogen may produce different maturation signals by activating DCs induce a given type of immune response. In this study, we observed the profiles and amounts of cytokine production of DCs stimulated with P. gingivalis and T. forsythensis compared with E. coli, to see whether the periodontal pathogens may induce different response of dendritic cells in the innate immunity.
Status | Recruiting |
Enrollment | 20 |
Est. completion date | |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 20 Years and older |
Eligibility |
Inclusion Criteria: - Healthy Exclusion Criteria: |
Observational Model: Defined Population, Time Perspective: Cross-Sectional
Country | Name | City | State |
---|---|---|---|
Taiwan | National Taiwan University Hospital | Taipei |
Lead Sponsor | Collaborator |
---|---|
National Taiwan University Hospital |
Taiwan,
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT02618486 -
The Effects of Obesity on Non Surgical Periodontal Therapy
|
N/A | |
Recruiting |
NCT01785355 -
The Impact Of Periodontal Disease Treatment On The General Health Status In Chronic Haemodialyzed Patients
|
||
Completed |
NCT01639183 -
Power Toothbrush Use in Nursing Homes to Eliminate Mouth and Body Inflammation
|
N/A | |
Completed |
NCT02935322 -
Interaction Between Chlorhexidine and Fluoride
|
Phase 4 | |
Completed |
NCT00093236 -
Impact of Gum Infection on Heart Disease
|
N/A | |
Completed |
NCT03444363 -
Periodontal Treatment With Diode Laser in the Patients With Diabetes Melitus
|
N/A | |
Completed |
NCT03641989 -
Correlation Between Oral Health and Systemic Inflammation (COHESION)
|
N/A | |
Withdrawn |
NCT02202304 -
The Effects of Chlorhexidine/Thymol Varnish on Partial Denture Patient
|
Phase 4 | |
Recruiting |
NCT01568697 -
Oral Bacteria and Immune System Problems Involved in Gum Disease (Periodontitis)
|
||
Completed |
NCT04873505 -
Functional Validation of Lactobacillus Containing Oral Tablet
|
N/A | |
Completed |
NCT01521260 -
Implant Surface Decontamination in Peri-implantitis Treatment
|
N/A | |
Recruiting |
NCT00553007 -
The Relation Between Periodontal Disease and Metabolic Syndrome
|
N/A | |
Completed |
NCT01399034 -
Epigenetics, DNA Methylation Patterns and Periodontal Disease
|
N/A | |
Completed |
NCT00016835 -
Treating Periodontal Infection: Effects on Glycemic
|
Phase 2 | |
Completed |
NCT03540498 -
Study of Colonization of Strains L.Plantarum and L.Brevis in the Product AB-DENTALAC Chewing Gum
|
N/A | |
Completed |
NCT03775967 -
Estimation of Sialic Acid and IL10 Levels in Stage 1 and 2 Periodontitis Patients
|
||
Completed |
NCT02914743 -
Providing Preventive Periodontal Treatment to Hospitalized Patients With Diabetes
|
N/A | |
Completed |
NCT02894463 -
Study Aimed at Detecting Potential Abuse of Nitrous Oxide in Children During Dental Care
|
N/A | |
Completed |
NCT02289066 -
Impact of Periodontal Disease on Outcomes in Diabetes
|
N/A | |
Not yet recruiting |
NCT01718912 -
Periodontal Disease Treatment of a Physically Challenged Population
|
N/A |