Pediatric Obesity Clinical Trial
Official title:
Effects of Varied Macronutrient Composition on Weight Loss in Obese Adolescents
The aim of the proposed study is to provide important data on weight loss efficacy in overweight and obese adolescents on an isocaloric higher protein diet vs a lower protein diet utilizing the U.S. Department of Agriculture (USDA) MyPlate nutrition guide. The investigators hypothesize that the higher protein diet will result in greater weight loss due to increased satiety and better dietary adherence.
Aim 1 is to test the efficacy of a personalized higher protein weight loss intervention
compared to a lower protein intervention which use the USDA MyPlate nutrition guide.
It is hypothesized that participants randomly assigned to the higher protein dietary
treatment will lose more weight based on BMI-Z score over 12 weeks compared to participants
in the lower dietary protein treatment.
Aim 2 is to test if changes in subjective ratings of appetite differ by dietary treatment
(i.e. protein intake).
It is hypothesized that participants in the higher protein intervention will report a
decrease in hunger and an increase in fullness compared to participants in the lower protein
intervention.
Aim 3 is to test if change in the hexosamine biosynthetic pathway (HBP) measured at the rate
limiting step of glutamine fructose-6-phosphate amidotransferase (GFAT) and glycosylation
measured as O-linked N-acetylglucosamine (GlcNAc) transferase (OGT) differ by dietary
treatment.
It is hypothesized that participants randomly assigned to the higher protein dietary
treatment will have decreased change from baseline levels of GFAT and glycosylation (OGT) due
to decreased carbohydrate intake compared to the lower protein treatment.
Exploratory Aims: As exploratory aims, the investigators will test if the higher protein or
lower protein dietary treatments differentially alter glucose, insulin, cholesterol, and
triglycerides (markers of the metabolic syndrome).
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