Parkinson's Disease Clinical Trial
Official title:
A Randomized, Double Blind, Placebo-Controlled Study To Investigate The Effect Of E2007 On Pharmacodynamic Responses To Levodopa Among Patients With Parkinson's Disease Who Experience Dyskinesia And Motor Fluctuations
A randomized, double blind, placebo-controlled study employing a mixed parallel group and
fixed sequence cross-over design.
Patients will be randomized to one of two treatment groups ('E2007' or 'Placebo') in a 1:1
ratio and receive investigational drug treatment concomitant with their standard
individualized anti-Parkinsonian therapy for a total of six weeks. Investigational drug
treatment for patients in the E2007 treatment group will be started 2 mg E2007 o.d. but will
be escalated to 4 mg E2007 o.d. after three weeks.
n/a
Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Treatment
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