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Phase 1/2a Study of ANPD001 in Parkinson Disease — ASPIRO  

Parkinson Disease Clinical Trial

Official title:
Phase 1/2a Dose Escalation Study of ANPD001 in Sporadic Parkinson Disease

Clinical Trial Summary

This clinical trial is designed to test the safety and tolerability of injecting ANPD001 cells that will mature into dopamine-producing cells into the brain of participants with Parkinson Disease. All participants will have ANPD001 cells manufactured from their own previously collected cells.

Clinical Trial Description

Participants will undergo a surgical implantation of cells that will mature into dopamine-producing neurons under general anesthesia into a part of the brain where dopamine production is decreased in patients with Parkinson Disease. The effect on Parkinson Disease symptoms, safety and tolerability, and cell survival are assessed for 5 years post-transplant (with MRI and PET imaging scans of the brain). Safety and tolerability are assessed annually for an additional 10 years via telephone call (total follow-up of 15 years) ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06344026
Study type Interventional
Source Aspen Neuroscience
Contact
Status Enrolling by invitation
Phase Phase 1
Start date January 23, 2024
Completion date April 30, 2030
View Details
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