Clinical Trials Logo
NCT number NCT03497884
Study type Interventional
Source Hangzhou Normal University
Contact Yu-Feng Zang, M.D.
Phone +86571-28867717
Status Recruiting
Phase N/A
Start date September 4, 2017
Completion date April 30, 2018

Clinical Trial Summary

Parkinson's disease (PD) patients have some problem with self-initiated movement task. Compared with health controls, task meta-analysis found that PD patients showed abnormal activation in pre-supplementary motor area (pre-SMA) and putamen. And the functional connectivity has already been reported between pre-SMA and putamen in 2013. Repetitive Transcranial Magnetic Stimulation (rTMS) is a sage and painless technique to activate cortical areas. The deep brain structure can be activated via stimulating superficial cortex by rTMS. For investigating the mechanism of self-initiated movement, this project is using functional magnetic resonance imaging (fMRI) to individualize the precise localization in motor area and combining rTMS to activate putamen.

Clinical Trial Description

Healthy subject is recruiting in this project. High and low frequency rTMS will be performed, respectively. For the l-Hz sessions (low frequency), stimulation is delivered at 100% of the subject's resting motor threshold at 1 Hz continuously over 30 min for a total of 1,800 pluses. The 10-Hz stimulation is delivered at 100% of the subject's resting motor threshold via 60 trains of 3-s 10-Hz rTMS (30 pulses per train).

Study Design

Related Conditions & MeSH terms

See also
  Status Clinical Trial Phase
Recruiting NCT03272230 - Assessment of Apathy in a Real-life Situation, With a Video and Sensors-based System N/A
Recruiting NCT03257046 - Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ITI-214 in Parkinson's Disease Phase 1/Phase 2
Recruiting NCT03295786 - Clinical Study to Test the Safety of CDNF by Brain Infusion in Patients With Parkinson's Disease Phase 1/Phase 2
Completed NCT03103399 - Efficacy and Tolerability of Nebicapone in Parkinson's Disease Patients With "Wearingoff" Phenomenon Phase 2
Suspended NCT03104725 - Does N-Acetylcysteine Decrease Spontaneous Oxidation of Central Neural Dopamine in Parkinson's Disease? N/A
Recruiting NCT03014050 - Bio Electro Stimulation Therapy for Parkinson's Disease N/A
Recruiting NCT03045211 - Post-Physical Therapy Extension of In-Home Dynamic Standing Table Use in Parkinson Disease N/A
Recruiting NCT02601586 - Effects of PR Oxycodone and of Levodopa, vs Placebo, on Central Neuropathic Pain in Parkinson's Disease Phase 2/Phase 3
Recruiting NCT02869945 - Compensation Mechanisms in Parkinson's Disease N/A
Recruiting NCT03192046 - Bracing for Walking in Parkinson's Disease N/A
Recruiting NCT03143374 - Positron Emission Tomography (PET) Imaging of Tau Pathology in Neurodegenerative Disease N/A
Recruiting NCT02897063 - Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure Phase 1
Recruiting NCT02823158 - Bilateral Pallidal Stimulation in Patients With Advanced Parkinson's Disease-LATESTIM N/A
Not yet recruiting NCT02855021 - Prediction of Dementia in Parkinson's Disease by Measuring Cerebral Metabolism With PET Scan N/A
Recruiting NCT03288909 - Ultra High Field Magnetic Resonance Imaging as a Biomarker for Premotor Parkinson's Disease N/A
Recruiting NCT02718560 - Handwriting Rehabilitation in Parkinson Disease N/A
Completed NCT02547506 - Comparison of Cardiorespiratory Fitness Among Regular Exercisers With and Without Parkinson Disease and Across Different Modes of Group Exercise N/A
Completed NCT02763891 - Effect of Body Suspension and Tilting Exercises in Parkinson's Disease N/A
Recruiting NCT02795663 - Deep Brain Stimulation and Parkinson's Disease Phase 0
Recruiting NCT02205216 - Can tDCS Enhance Efficacy of Rehabilitative Intervention for Freezing of Gait in Parkinson's Disease? N/A