Parkinson Disease Clinical Trial
— PSYCHO-PERFOfficial title:
Study About Personality, as a Predictive Factor of Therapeutic Response on Quality of Life After Continuous Perfusion of Dopaminergic Drugs (by Subcutaneous Apomorphine Infusion or Intrajejunal Infusion of Levodopa-carbidopa), in Parkinson's Disease
Verified date | January 2019 |
Source | University Hospital, Toulouse |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The aim of the study is to evaluate if patients' personality could be considerate as predictive factor of quality of life after the establishment of continuous infusion of dopaminergic treatments to observe if there are predictive personality's profiles of specific therapeutic response (Deep Brain Stimulation (DBS) of the subthalamic nucleus (STN) or continuous infusion).
Status | Active, not recruiting |
Enrollment | 60 |
Est. completion date | June 18, 2021 |
Est. primary completion date | December 18, 2020 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Patients having Parkinson's disease according to United Kingdom Parkinson's Disease Society Brain Bank (UKPDSBB) criteria - All Parkinson's patients presenting motor fluctuations and/or disabling dyskinesia and in need of the establishment of a second line treatment by subcutaneous apomorphine infusion or intrajejunal infusion of levodopa-carbidopa in the context of classical care of their Parkinson's disease - Patient able to give its free and informed consent - Patient having a social security Exclusion Criteria: - Patients presenting atypical Parkinson's syndrome - Patients having a deep brain stimulation - Patient having a psychiatric disease such as: mood disorders, psychotic disorder… - Patients presenting a cognitive decline evaluated by a Montreal Cognitive Assessment (MoCA) score inferior to 24 - None ability to give its consent - Patients unable to realize the tests provided in the context of this study - Patients under supervision, curators, or legal guardian - Patients non-affiliated to a social security - Patients in exclusion period of another study. |
Country | Name | City | State |
---|---|---|---|
France | UHToulouse | Toulouse |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Toulouse |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | percent of improvement of quality of life score at 6 months after the beginning of the second line treatment | Evaluation of life quality using Parkinson's Disease Questionnaire (PDQ-39) scale before (day 1) and after (6 month) the starting of perfusion treatment | day 1 | |
Primary | percent of improvement of quality of life score at 6 months after the beginning of the second line treatment | Evaluation of life quality using PDQ-39 scale before and after the starting of perfusion treatment | 6 months |
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