Parkinson Disease Clinical Trial
Official title:
Accuracy of Markerless 3D Motion Capture Evaluation to Differentiate Between On/Off Status in Parkinson's Disease After Deep Brain Stimulation
NCT number | NCT03607721 |
Other study ID # | DARI-DBS |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | March 1, 2017 |
Est. completion date | July 1, 2017 |
Verified date | July 2018 |
Source | Instituto de Neurologia y Neurocirugia Hospital Zambrano Hellion |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Body motion evaluation (BME) by markerless systems is increasingly being considered as an
alternative to traditional marker-based technology because they are faster, simpler, and less
expensive. They are increasingly used in clinical settings in patients with movement
disorders, however, the wide variety of systems available make results conflicting.
The objective of this study was to determine if a markerless 3D motion capture system is a
useful instrument to objectively differentiate between Parkinons's Disease (PD) patients with
Deep Brain Stimulation (DBS) in On and Off state and controls; and its correlation with the
evaluation by means of Unified Parkinson's Disease Rating Scale (UPDRS).
Six PD patients who underwent DBS bilaterally in the subthalamic nucleus were evaluated using
BME and UPDRS-III with DBS turned On and Off. BME of 16 different movements in six controls
paired by age and sex was compared with PD patients with DBS in On and Off states.
Kinematic data obtained with this markerless system could contribute to the discrimination
between PD patients and healthy controls. This emerging technology may help to clinically
evaluate PD patients more objectively.
Status | Completed |
Enrollment | 12 |
Est. completion date | July 1, 2017 |
Est. primary completion date | July 1, 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 40 Years to 80 Years |
Eligibility |
Inclusion Criteria: - Patients with Diagnosis of Parkinson's Disease by United Kingdom Parkinson's Disease Society Brain Bank Clinical Diagnostic Criteria - Submitted to subthalamic DBS implantation a minimum of 3 months prior to the evaluation. Exclusion Criteria: - Patients with physical disability (i.e. wheelchair, cane, assistance to daily living activities) - History of stroke and physical disability - Another neurological disorder other than PD - Recent head and limb trauma that limits movement - Treatment with antipsychotics or recent botulinum toxin treatment. |
Country | Name | City | State |
---|---|---|---|
Mexico | Instituto de Neurologia y Neurocirugia Hospital Zambrano Hellion | San Pedro Garza Garcia | NL |
Lead Sponsor | Collaborator |
---|---|
Instituto de Neurologia y Neurocirugia Hospital Zambrano Hellion |
Mexico,
Bovonsunthonchai S, Vachalathiti R, Pisarnpong A, Khobhun F, Hiengkaew V. Spatiotemporal gait parameters for patients with Parkinson's disease compared with normal individuals. Physiother Res Int. 2014 Sep;19(3):158-65. doi: 10.1002/pri.1579. Epub 2013 Dec 23. — View Citation
Ceseracciu E, Sawacha Z, Cobelli C. Comparison of markerless and marker-based motion capture technologies through simultaneous data collection during gait: proof of concept. PLoS One. 2014 Mar 4;9(3):e87640. doi: 10.1371/journal.pone.0087640. eCollection 2014. — View Citation
Chen SW, Lin SH, Liao LD, Lai HY, Pei YC, Kuo TS, Lin CT, Chang JY, Chen YY, Lo YC, Chen SY, Wu R, Tsang S. Quantification and recognition of parkinsonian gait from monocular video imaging using kernel-based principal component analysis. Biomed Eng Online. 2011 Nov 10;10:99. doi: 10.1186/1475-925X-10-99. — View Citation
Dewey DC, Miocinovic S, Bernstein I, Khemani P, Dewey RB 3rd, Querry R, Chitnis S, Dewey RB Jr. Automated gait and balance parameters diagnose and correlate with severity in Parkinson disease. J Neurol Sci. 2014 Oct 15;345(1-2):131-8. doi: 10.1016/j.jns.2014.07.026. Epub 2014 Jul 19. — View Citation
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Ferrarin M, Rizzone M, Bergamasco B, Lanotte M, Recalcati M, Pedotti A, Lopiano L. Effects of bilateral subthalamic stimulation on gait kinematics and kinetics in Parkinson's disease. Exp Brain Res. 2005 Jan;160(4):517-27. Epub 2004 Oct 22. — View Citation
Fry AC, Herda TJ, Sterczala AJ, Cooper MA, Andre MJ. Validation of a motion capture system for deriving accurate ground reaction forces without a force plate. Big Data Anal. 2016;1(1):11. doi:10.1186/s41044-016-0008-y.
Galna B, Barry G, Jackson D, Mhiripiri D, Olivier P, Rochester L. Accuracy of the Microsoft Kinect sensor for measuring movement in people with Parkinson's disease. Gait Posture. 2014 Apr;39(4):1062-8. doi: 10.1016/j.gaitpost.2014.01.008. Epub 2014 Jan 22. — View Citation
Moodie P. Validation : Reviewing 3D Motion Capture Technology Types and What the Gold Standard Should Be for Human Movement . Lenexa, Kansas
Mündermann L, Anguelov D, Corazza S, Chaudhari AM, Andriacchi TP. Validation of a markerless motion capture system for the calculation of lower extremity kinematics.; 2005.
Perrott MA, Pizzari T, Cook J, McClelland JA. Comparison of lower limb and trunk kinematics between markerless and marker-based motion capture systems. Gait Posture. 2017 Feb;52:57-61. doi: 10.1016/j.gaitpost.2016.10.020. Epub 2016 Oct 31. — View Citation
Rocha AP, Choupina H, Fernandes JM, Rosas MJ, Vaz R, Silva Cunha JP. Parkinson's disease assessment based on gait analysis using an innovative RGB-D camera system. Conf Proc IEEE Eng Med Biol Soc. 2014;2014:3126-9. doi: 10.1109/EMBC.2014.6944285. — View Citation
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Wassom D, Fry A, Moodie N. Repeatability of 3D markerless motion capture and how it could affect between-session variability. J Appl Hum Mov. 2015;1(1):21-25.
* Note: There are 14 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Shoulder Flexion (right and left), Shoulder Extension (right and left), Internal Shoulder Rotation (right and left), External Shoulder Rotation (right and left), Maximum shoulder abduction (right and left) | Measured by DARI Body Motion Analysis. Range of movement, measured in degrees. | 1 day: Test is done twice. First with DBS in Off state and then repeated 1 hour after DBS has been turned to On state. | |
Primary | Bilateral squat depth, Lunge Distance (right and left), Step Length (right and left), Step Width (right and left) | Measured by DARI Body Motion Analysis. Range of movement, measured in centimeters. | 1 day: Test is done twice. First with DBS in Off state and then repeated 1 hour after DBS has been turned to On state. | |
Primary | Trunk Rotation, Trunk Flexion, Trunk Extension | Measured by DARI Body Motion Analysis. Range of movement, measured in degrees. | 1 day: Test is done twice. First with DBS in Off state and then repeated 1 hour after DBS has been turned to On state. | |
Primary | Anterior-posterior hip displacement, Medial-lateral hip displacement | Measured by DARI Body Motion Analysis. Patients are asked to outstretch their arms to the sides, extend their neck and close their eyes during 10 seconds. The hip displacement that happens during this time is recorded and measured in centimeters. | 1 day: Test is done twice. First with DBS in Off state and then repeated 1 hour after DBS has been turned to On state. | |
Primary | Cadence | Measured by DARI Body Motion Analysis. Measured in steps/minute. | 1 day: Test is done twice. First with DBS in Off state and then repeated 1 hour after DBS has been turned to On state. | |
Primary | Speed or velocity | Measured by DARI Body Motion Analysis. Measured in meters/second. | 1 day: Test is done twice. First with DBS in Off state and then repeated 1 hour after DBS has been turned to On state. | |
Primary | Stride length | Measured by DARI Body Motion Analysis. It is the distance between any two successive points of heel contact of the same foot. Measured in centimeters. | 1 day: Test is done twice. First with DBS in Off state and then repeated 1 hour after DBS has been turned to On state. | |
Secondary | Speech | Unified Parkinson's Disease Rating Scale Section III (motor examination). Score ranges from 0-4 where 0 is normal and 4 is unintelligible. | 1 day: Test is done once with DBS in Off state. | |
Secondary | Facial Expression | Unified Parkinson's Disease Rating Scale Section III (motor examination). Score ranges from 0-4 where 0 is normal and 4 is severe or complete loss of facial expression. | 1 day: Test is done once with DBS in Off state. | |
Secondary | Tremor at Rest | Unified Parkinson's Disease Rating Scale Section III (motor examination). Head, upper and lower extremities. Score ranges from 0-4 where 0 is absent and 4 is marked in amplitude and present most of the time. | 1 day: Test is done once with DBS in Off state. | |
Secondary | Action or Postural Tremor of Hands | Unified Parkinson's Disease Rating Scale Section III (motor examination). Score ranges from 0-4 where 0 is absent and 4 is marked in amplitude and interferes with feeding. | 1 day: Test is done once with DBS in Off state. | |
Secondary | Rigidity | Unified Parkinson's Disease Rating Scale Section III (motor examination). Judged on passive movement of major joints with patient relaxed in a sitting position. Score ranges from 0-4 where 0 is absent and 4 is severe, range of motion achieved with difficulty. | 1 day: Test is done once with DBS in Off state. | |
Secondary | Finger Taps | Unified Parkinson's Disease Rating Scale Section III (motor examination). Tapping of thumb and index finger in rapid succession. Score ranges from 0-4 where 0 is normal and 4 is can barely perform the task. | 1 day: Test is done once with DBS in Off state. | |
Secondary | Hand Movements | Unified Parkinson's Disease Rating Scale Section III (motor examination). Opening and closing hands in rapid succession. Score ranges from 0-4 where 0 is normal and 4 is can barely perform the task. | 1 day: Test is done once with DBS in Off state. | |
Secondary | Rapid Alternating Movements of Hands | Unified Parkinson's Disease Rating Scale Section III (motor examination). Pronation-supination in rapid succession. Score ranges from 0-4 where 0 is normal and 4 is can barely perform the task. | 1 day: Test is done once with DBS in Off state. | |
Secondary | Leg Agility | Unified Parkinson's Disease Rating Scale Section III (motor examination). Tapping heel on the ground in rapid succession picking up entire leg. Score ranges from 0-4 where 0 is normal and 4 is can barely perform the task. | 1 day: Test is done once with DBS in Off state. | |
Secondary | Arising from Chair | Unified Parkinson's Disease Rating Scale Section III (motor examination). Patient attempts to rise from straight-backed chair with arms folded across chest. Score ranges from 0-4 where 0 is normal and 4 is unable to arise without help. | 1 day: Test is done once with DBS in Off state. | |
Secondary | Posture | Unified Parkinson's Disease Rating Scale Section III (motor examination). Score ranges from 0-4 where 0 is normal, erect and 4 is marked flexion with extreme abnormality of posture. | 1 day: Test is done once with DBS in Off state. | |
Secondary | Gait | Unified Parkinson's Disease Rating Scale Section III (motor examination). Score ranges from 0-4 where 0 is normal and 4 is cannot walk at all, even with assistance. | 1 day: Test is done once with DBS in Off state. | |
Secondary | Postural Stability | Unified Parkinson's Disease Rating Scale Section III (motor examination). Response to sudden, strong posterior displacement produced by pull on shoulders while patient erect with eyes open and feet slightly apart. Score ranges from 0-4 where 0 is normal and 4 is unable to stand without assistance. | 1 day: Test is done once with DBS in Off state. | |
Secondary | Body Bradykinesia and Hypokinesia | Unified Parkinson's Disease Rating Scale Section III (motor examination). Combination of slowness, hesitancy, decreased arm swing, small amplitude, and poverty of movement in general. Score ranges from 0-4 where 0 is normal and 4 is unable to stand without assistance. | 1 day: Test is done once with DBS in Off state. |
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