Parkinson Disease Clinical Trial
Official title:
The Effect of High Versus Low Frequency Repetitive Transcranial Magnetic Stimulation on Motor Dysfunction in Parkinson's Disease; Which is More Beneficial?
Verified date | September 2020 |
Source | Assiut University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The aim of the study is to compare high versus low frequency rTMS on motor dysfunction in PD.
Forty patients with PD participated in the study.
The patients were randomly assigned into two groups; the first group received 1Hz and the 2nd
one received 20 Hz rTMS daily for 10 days 5 sessions every week. The doctors who assess the
patients clinically is blind for the frequency of rTMS, also patients don't know which type
of stimulation they received. The patients were followed up before and after the 10 sessions
and one month later.
Status | Completed |
Enrollment | 40 |
Est. completion date | February 25, 2018 |
Est. primary completion date | February 25, 2018 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 50 Years to 80 Years |
Eligibility |
Inclusion Criteria: - All PD patients who were diagnosed according to UK bank criteria for PD. Exclusion Criteria: - History of repeated head injury. - History of repeated cerebrovascular strokes - History of defined encephalitis - Oculogyric crisis, supra nuclear gaze palsy. - Family history of more than one relative - severe dementia, MMSE < 23, severe depression - Cerebellar signs - Babiniski sign - Hydrocephalus or intracranial lesion on neuroimaging - Patients with intracranial on neuroimaging - Patients with intracranial metallic device or pacemaker - Patients who were unable to give informed consent because of severe anesthesia, or cognitive deficit |
Country | Name | City | State |
---|---|---|---|
Egypt | Eman Khedr | Assiut |
Lead Sponsor | Collaborator |
---|---|
Assiut University |
Egypt,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | change in motor disability | Measure the change in motor disability by using UPDRS and self assessment scale | one month | |
Secondary | Changes in Cortical excitability | Measure the changes in cortical excitability using magnetic stimulation appratus | Two weeks |
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