To Assess the Safety of Continuous IV Administration of Plerixafor &

Status Terminated

Clinical Trial Summary

A dose escalation trial to assess the safety of plerixafor in patients with advanced pancreatic, high grade serous ovarian and colorectal cancer. To identify the proof of mechanism, by demonstrating alterations in T-cell tumour distribution, ideally associated with loss of tumour cells, measured by immunostaining, and changes in FDG uptake.

Clinical Trial Description

This is a prospective, non-randomised, open label, Phase I, dose escalation trial of plerixafor in patients with histological documentation of advanced pancreatic, high grade serous ovarian or colorectal adenocarcinoma. We will investigate the feasibility of administering plerixafor in terms of safety, and will try to identify the proof of mechanism in patients. This trial will follow the standard 3+3, Phase I trial design, leading to a treatment expansion phase to confirm the RP2D. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03277209
Study type	Interventional
Source	Weill Medical College of Cornell University
Contact
Status	Terminated
Phase	Phase 1
Start date	July 25, 2017
Completion date	December 30, 2019

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To Assess the Safety of Continuous IV Administration of Plerixafor and Assess Impact on the Immune Microenvironment in Patients With Pancreatic, Ovarian and Colorectal Adenocarcinomas

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms