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Irreversible Electroporation + Nivolumab for Patients With Metastatic Pancreatic Cancer — CHECKPOINT  

Pancreas Cancer Clinical Trial

Official title:
Irreversible Electroporation in Combination With Immune Checkpoint Inhibition, in Patients With Metastatic Pancreatic Cancer - A Prospective, Phase 2 Study

Clinical Trial Summary

The trial investigates the safety and efficacy of irreversible electroporation in combination with checkpoint inhibition in patients with metastatic pancreatic cancer.

Clinical Trial Description

The trial is designed as an investigator initiated prospective phase 2 study in patients with metastatic pancreatic cancer (PC) to determine the efficacy and safety of checkpoint inhibition administered concurrently with irreversible electroporation. A recently published preclinical study by Zhao et al. (2019) showed that the combination of IRE and PD-1-inhibitor suppressed the tumour growth and increased the survival of mice bearing pancreatic cancer. The aim of the trial is to initiate an abscopal response, leveraging the patient's immune system in eliciting a sufficient immune response. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05435053
Study type Interventional
Source Zealand University Hospital
Contact
Status Terminated
Phase Phase 2
Start date September 8, 2022
Completion date August 30, 2023
View Details
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