Pain Clinical Trial
Official title:
Relation Between Cachexia, Diabetes and periNeural Invasion in PANcreatic Cancer- Biomarkers Substudy
The purpose of this study is to determine the interrelationship between cachexia, neural invasion and diabetes in patients with pancreatic cancer. Thus the investigators propose to identify the protein expression levels of Activin and Midkine in plasma of patients with different stages of pancreatic adenocarcinoma compared with healthy patients and to evaluate the possible correlation with diabetes, tumor size and tumor stage.
In this study, the investigators will prospectively evaluate pancreatic adenocarcinoma
patients with or without cachexia, perineural invasion and diabetes.
Patients with pancreatic ductal adenocarcinoma, based on the results of an endoscopic
ultrasonography (EUS) biopsy or surgery were enrolled at the diagnosis and blood samples are
drawn.
Thus the investigators propose to identify the protein expression levels of Activin and
Midkine in plasma of patients with different stages of pancreatic adenocarcinoma compared
with benign pancreatic disorders and healthy patients and to evaluate the possible
correlation with diabetes, tumor size and tumor stage.
Furthermore, the investigators propose to identify the prognostic role of these biomarkers in
the development of metastasis and survival in patients with adenocarcinoma, with and without
diabetes and cachexia; to identify a new biomarker predictive of cachexia and eventually to
select patients likely to benefit from treatment with antagonists of activin (or hypoglycemic
treatment) and investigating the role of invasion neural in the appearance of cachexia in
patients with pancreatic adenocarcinoma.
Follow-up: with phone-calls on an every 6 month, for up to 2 years, retaining the following
data: survival, date of decease and its direct cause, the presence of tumor recurrence.
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