Pain, Postoperative Clinical Trial
Official title:
Neuroplasticity of Pain Pathways and Corneal Afferent Regeneration Following Corneal Crosslinking (CXL) in Keratoconus
Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).
Status | Recruiting |
Enrollment | 60 |
Est. completion date | December 2025 |
Est. primary completion date | August 2025 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 8 Years to 35 Years |
Eligibility | Inclusion Criteria: CXL Group - Age 8-35 years - Clinical diagnosis of keratoconus and seeking CXL treatment - English speaking ability sufficient to comprehend consent with parental assistance - MRI compatible - Ability to lie still for an MRI session (60 minutes) Control Group - Age 8-35 years - No diagnosis of keratoconus - English speaking ability sufficient to comprehend consent with parental assistance - MRI compatible - Ability to lie still for an MRI session (60 minutes) Exclusion Criteria (Both Groups): - Claustrophobic - Weight > 285 lbs (weight limit of the MRI table) - Significant medical history, including: Current DSM-IV-TR axis I psychiatric disorders. Chronic pain Significant head injury Seizures Brain tumor Cerebrovascular accident Neurological disease aside from migraine HIV-AIDs Prescription medication strongly implicated in causing dry eyes - Magnetic implants or metal-containing tattoos on their chest or above - Pregnancy - History of contact lens wear - Any allergic response to a numbing eyedrop in the past |
Country | Name | City | State |
---|---|---|---|
United States | Boston Children's Hospital | Boston | Massachusetts |
Lead Sponsor | Collaborator |
---|---|
Boston Children's Hospital |
United States,
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* Note: There are 21 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Neural activity related to pain. | Pain-related brain activation measured with fMRI. | 1 year | |
Primary | Corneal nerve morphology. | Afferent nerve fiber morphology measured with IVCM. | 1 year |
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