Drinking Effect of Electrolyzed Alkaline Reduced Water on Oxidative Stress and Fatigue After Intense Exercise

Oxidative Stress Clinical Trial

Official title:

Effects of Alkaline-reduced Water Generated From Electrolyzed Device (CGM MWPI-2101) on High-intensity Exercise-induced Oxidative Stress and Fatigue in Young Male Healthy Adults: Controlled, Randomized, Double-blind Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05673395
• Other study ID #: EMB-2022-02
• Status: Completed
• Phase: N/A
• Start date: June 13, 2022
• Est. completion date: June 30, 2022

Study information

• Verified date: January 2023
• Source: Wonju Severance Christian Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The goal of this clinical trial is to test the drinking effect of electolyzed alkaline reduced water (ARW) generated from alkaline ionizer (CGM MWPI-2101) on oxidative stress and fatigue after high-intensity exercise in healthy people. The main question[s] it aims to answer are: - [question 1] Can pH 9.5 EARW reduce oxidative stress compared to purified water (PW) - [question 2] Can pH 9.5 EARW decrease fatigue markers in blood Participants will drink water from the experimental device after high-intensity exercise. Blood sample will be collected before exercise, after highly intensive exercise, and after then 15 min. of drinking water. Researchers will compare EARW group and PW group to see the anti-oxidative and anti-fatigue effects.

Description:

This study was designed as a randomized, controlled, crossover, double-blind clinical trial with a single intervention of ARW intake (pH 9.5, 10 mL/kg body weight) after highly intense exercise. The participants were divided into two groups, wherein they consumed either purified water (PW group) or EARW (EARW group). Blood samples were collected before exercise, immediately after exercise, and 15 min after drinking water. For the anti-oxidative effect, ROS, NO, GPx, and MDA levels were measured. For the anti-fatigue effect, latate, lactate dehydrogenase, phosphate and calcium were measured.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 24
• Est. completion date: June 30, 2022
• Est. primary completion date: June 30, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 19 Years to 25 Years

Eligibility

Inclusion Criteria:

• healthy male participants aged 19-25 years
• physically active with a normal body mass index (BMI)
• had not smoked for 3 months or consumed alcohol for more than a week prior to the start of the study.

Exclusion Criteria:

• any kind of visible or known disease
• hypertension,
• musculoskeletal injuries in the previous three months,
• breathing dif?culties,
• metabolic diseases,
• autoimmune disease,
• rash,
• urticaria.

Related Conditions & MeSH terms

• Fatigue
• Oxidative Stress

Intervention

Device:
• Electrolyzed alkaline reduced water generator
Participants drink water (10 mL/kg body weight) generated from the device after intensive excercise.

Locations

Country	Name	City	State
Korea, Republic of	Wonju Severance Christian Hospital	Wonju	Ganwon-do

Sponsors (2)

Lead Sponsor	Collaborator
Kyu Jae Lee	Ceragem Inc.

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	EARW consumption is effective in reducing oxidative stress	Reactive oxygen species, nitric oxide, glutathione peroxidase, malondialdehyde	15 minutes
Secondary	The effects of EARW consumption on exercise-induced fatigue markers in healthy young adults	Lactate levels, phosphate levels, cytokines	15 minutes