| Eligibility |
Inclusion Criteria:
1. Those voluntarily participating and signing the ICF.
2. Those aged 18-70 years old (including 18 and 70 years old), without restriction on
male and female
3. Those failing to control their body weight in previous diet therapy alone.
4. Those voluntarily following the medication, diet and exercise requirements decided by
the investigators.
5. Those with a stable body weight (patient reported body weight change < 5 kg) in last 3
months.
6. Those with BMI = 30 kg/m2 (obese) or BMI = 27 kg/m2 (overweight) accompanied by at
least one treated or untreated related metabolic abnormality (hypertension,
dyslipidemia, type 2 diabetes). Those with untreated hypertension defined as SBP = 140
mmHg or DBP = 90 mmHg; untreated dyslipidemia defined as LDL-C = 4.1 mmol/L, TG = 1.7
mmol/L, TC = 5.7 mmol/L or HDL-C < 1.0 mmol/L in male and < 1.3 mmol/L in female.
7. Those with type 2 diabetes should additionally meet the following inclusion criteria:
1. Those diagnosed as type 2 diabetes according to WHO (1999) Diagnostic and
Classification Criteria at the time of screening;
2. Those receiving diet and exercise therapy alone, or receivig metformin,
sulfonylureas, glycosidase inhibitors and glinides alone or in combination on the
basis of diet and exercise therapy, with their treatment remaining stable at
least 3 months before screening (with original documents such as prescriptions
provided);
3. Those with HbA1c of 7.0-10.0% (inclusive);
4. Those with FPG < 13.3 mmol/L (240 mg/dL).
Exclusion Criteria:
Subjects who meet one of the following exclusion criteria will be excluded.
1. Those with type 1 diabetes or secondary diabetes.
2. Those with acute metabolic complications such as diabetic ketoacidosis or
hyperglycemia (coma) within 6 months before screening.
3. Those with 2 or more severe hypoglycemia events (hypoglycemia with severe cognitive
impairment and need other measures to help them recover) without obvious inducement
within 3 months before screening.
4. Those receiving GLP-1 receptor agonist, DPP-4 inhibitors, SGLT-2 inhibitor, or insulin
therapy within 3 months prior to screening.
5. Those with obesity caused by endocrine diseases such as Cushing's syndrome.
6. Patients taking drugs that can significantly increase weight in the 3 months before
screening, including systemic glucocorticoid (except cumulative or continuous use of
less than 14 days).
7. Those using OTC weight-loss drugs or appetite inhibitors (including traditional
Chinese medicine as weight-loss drugs) within 1 month before screening, or use
prescription weight-loss drugs (such as fentanyl, sibutramine, orlistat) or lipid
dissolving injection (such as fat dissolving needle) within 3 months before screening.
8. Those with binge eating behavior in the past, that is, eating a large amount of food
in a short period of time with a sense of loss of control.
9. Those who have treated or plan to treat obesity (during the trial) with surgery or
body weight loss devices.
10. Those with a past or family history of MTC (grandparents, parents, siblings), or those
whose genetic diseases are prone to induce MTC and MEN2.
11. Those with thyroid nodules of unknown etiology at the time of screening which is
considered clinically significant by the investigator (calcitonin is more than 50
pg/ml, which is only allowed to be retested once).
12. Those with a past history or found to have hyperthyroidism or hypothyroidism or
subclinical hypothyroidism at the time of screening [TSH > 6 mIU/L].
13. Those with history of pancreatic cancer, acute or chronic pancreatitis, or with acute
or chronic pancreatitis at the time of screening, or having blood amylase or lipase =
3 times ULN.
14. Those with acute gallbladder disease (cholecystitis, gallstone) more than 2 times in 1
year before screening.
15. Those with MDD, anxiety disorder or other mental illnesses or with the PHQ-9 score =
15 at screening
16. Those with the following cardiovascular and cerebrovascular diseases within 6 months
before screening: decompensated cardiac insufficiency (NYHA Class III-IV), UA or AMI,
CVA or stroke.
17. Those with a history of heart valve replacement, CABG or other PTCA including
percutaneous coronary intervention.
18. Those who fail to control their blood pressure effectively, with SBP = 160 mmHg or DBP
= 100 mmHg.
19. Those with a history of malignancy in the past 5 years, not including cervical
epithelial carcinoma, squamous cell carcinoma or basal cell carcinoma of skin that
have been clinically cured within 5 years.
20. Those with known proliferative retinopathy or maculopathy.
21. Those with a history of major surgical operations (intrathoracic, intracranial,
intraperitoneal, etc.) within 6 months, or planning to perform operations that may
interfere with the completion or compliance of the study.
22. Those with a history of organ transplantation.
23. Those with ADIS or syphilis at the time of screening, or whose serum virological test
shows hepatitis C virus antibody or hepatitis B surface antigen and hepatitis B core
antibody are positive at the time of screening.
24. Those with AST or ALT > 3.0-fold ULN, or total bilirubin > 2.0-fold ULN at the time of
screening.
25. Those with eGFR < 60 mL/min/1.73 m2 at the time of screening.
26. Those with a history of drug abuse (heavy and repeated use of dependent drugs or
substances not related to medical purposes, including addictive and habitual drugs,
causing physical and mental dependence) in 5 years before screening and alcohol
dependence (long-term heavy drinking, causing physical and mental dependence, male
drinking more than 14 units of alcohol per week, and female drinking more than 7 units
per week) (1 unit alcohol = 360 mL beer or 45 mL spirits with 40% alcohol content or
150 mL wine)].
27. Female who are known to be pregnant (determined by pregnancy test at the time of
screening) or who are breast-feeding or who plan a pregnancy during the study and are
unwilling to take effective contraceptive measures (including partners).
28. Those participating in other intervention clinical trials within 3 months prior to
screening.
29. Those known to be allergic to GLP-1 receptor agonist.
30. Those with any serious systemic diseases as determined by the investigator, or other
diseases as believed by the investigator to be possible to interfere with the results
of this study or abnormal laboratory tests with clinical significance.
31. Those who, according to the opinion of investigators, are not suitable to participate
in clinical trials, including those who are physically or psychologically unable to
comply with the protocol.
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