Differences in Sitting Versus Standing on Metabolic and Cardiovascular Measurements

Overweight and Obesity Clinical Trial

Official title:

Differences in Sitting Versus Standing on Metabolic and Cardiovascular Measurements

Clinical Trial Details — Status: Enrolling by invitation

Administrative data

• NCT number: NCT03927638
• Other study ID #: 17-18-861
• Status: Enrolling by invitation
• Start date: November 11, 2018
• Est. completion date: May 15, 2024

Study information

• Verified date: October 2023
• Source: Montclair State University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This investigations examined the effect that posture has on metabolic and cardiovascular measurements. Further, it will explore the potential for body weight status or physical activity to influence these relationships. All subjects will complete a seated condition and a standing condition in a counterbalanced manner.

Description:

The purpose of the present study was to evaluate both metabolic and cardiovascular responses to acute bouts of computer work while sitting and standing. Cardiovascular measurements were made using continuous non-invasive blood pressure monitoring and metabolic measurements were made using indirect calorimetry. Subjects will be grouped and analyzed based upon the weight status of the subject. All subjects will complete a seated condition and a standing condition in a counterbalanced manner. Investigators hypothesize that metabolic and cardiovascular responses will be elevated in the standing condition compared to sitting.

Recruitment information / eligibility

• Status: Enrolling by invitation
• Enrollment: 80
• Est. completion date: May 15, 2024
• Est. primary completion date: May 15, 2024
• Gender: All
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• healthy adult

Exclusion Criteria:

• Have a history of cancer, cardiac issues, hypertension, pulmonary disease, stroke, neurological or muscular dystrophy, uncontrolled diabetes, or any life threatening chronic conditions.
• Are currently being treated for infectious mononucleosis, hepatitis, pneumonia, or other infectious diseases.
• Are unable or unwilling to stand in one position continuously for 15-20 minutes at a time.
• Use nicotine products, or non-contraceptive hormonal therapy (birth control is okay).
• Are pregnant or trying to become pregnant.
• Are not between 18 and 50 years of age.

Related Conditions & MeSH terms

• Overweight
• Overweight and Obesity

Intervention

Behavioral:
• sit/stand
Subjects will be asked to both sit and stand during a single trial.

Locations

Country	Name	City	State
United States	Montclair State University	Montclair	New Jersey

Sponsors (1)

Lead Sponsor	Collaborator
Montclair State University

Country where clinical trial is conducted

United States, 

References & Publications (1)

Hosick PA, Willett JM, Matthews EL. Cardiovascular strain and metabolic rate are higher following 15 minutes of standing versus seated computer work. Eur J Prev Cardiol. 2020 Dec;27(19):2131-2133. doi: 10.1177/2047487319867402. Epub 2019 Jul 29. No abstract available. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Heart Rate	Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure heart rate based upon beat-by-beat finger pressure.	Approximately 15 minutes in each condition (sitting and standing)
Primary	Systolic Blood Pressure (SBP)	Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure SBP based upon beat-by-beat finger pressure.	Approximately 15 minutes in each condition (sitting and standing)
Primary	Diastolic Blood Pressure (DBP)	Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure DBP based upon beat-by-beat finger pressure.	Approximately 15 minutes in each condition (sitting and standing)
Primary	Oxygen Consumption	Oxygen consumption will be measured using indirect calorimetry.	Approximately 15 minutes in each condition (sitting and standing)
Primary	Carbon Dioxide Production	Carbon Dioxide will be measured using indirect calorimetry.	Approximately 15 minutes in each condition (sitting and standing)
Primary	Ventilation	Ventilation will be measured using indirect calorimetry.	Approximately 15 minutes in each condition (sitting and standing)
Primary	Respiratory Exchange Ration (RER)	RER will be calculated using oxygen and carbon dioxide value measure from indirect calorimetry.	Approximately 15 minutes in each condition (sitting and standing)
Secondary	Height	Standard stadiometer will be used to measure height in meters.	1 minute
Secondary	Weight	Standard scale will be used to measure weight in kilograms.	1 minute
Secondary	Body Mass Index (BMI)	Height in meters and weight in kilograms will be used to calculate BMI using the formula BMI = kg/m^2.	1 minute
Secondary	Body Composition	Body composition will be measured using air displacement plethysmography.	Approximately 15 minutes
Secondary	Total Peripheral Resistance (TPR)	Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be uses to estimate TPR based upon beat-by-beat finger pressure.	Approximately 15 minutes in each condition (sitting and standing)
Secondary	Stroke Volume	Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to estimate TPR based upon beat-by-beat finger pressure.	Approximately 15 minutes in each condition (sitting and standing)
Secondary	Cardiac Output (Q)	Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to estimate Q based upon beat-by-beat finger pressure.	Approximately 15 minutes in each condition (sitting and standing)
Secondary	Muscle Oxygen Saturation	Using Near-inferred spectroscopy muscle oxygen consumption will be monitored.	Approximately 15 minutes in each condition (sitting and standing)

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