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Average Volume-assured Pressure Support as Rescue Therapy in Obesity Hypoventilation Syndrome — AVAPS  

Obesity Hypoventilation Syndrome (OHS) Clinical Trial

Official title:
Outcome Measures of Auto-titrating Average Volume-assured Pressure Support (AVAPS) as Rescue Therapy After CPAP Titration Failure in Patients With Obesity Hypoventilation Syndrome: Adherence and Sleep Quality

Clinical Trial Summary

It remains unclear whether CPAP therapy should be prescribed if significant hypoxemia persists during CPAP titration, despite optimization of upper airway obstructive events, if maximum CPAP pressure is reached. The goal was to examine the effects of 6 months of home AVAPS therapy in patients with obesity hypoventilation syndrome as a potential option for patients who failed CPAP titration due to persistent hypoxemia.

Clinical Trial Description

Obesity hypoventilation syndrome (OHS) is one of the leading indications of home non-invasive ventilation (NIV) initiation. In patients with OHS, NIV improves daytime vigilance, decreases PaCO2, improves sleep quality, and improves physical activity. Thus, the primary aim of this study was to evaluate the effects of 6-month noninvasive ventilation with average volume-assured pressure support (AVAPS-AE) ventilation on objective sleep quality and adherence to therapy in stable patients with OHS who failed CPAP titration. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06442163
Study type Interventional
Source Assiut University
Contact
Status Completed
Phase N/A
Start date May 12, 2020
Completion date April 30, 2024
View Details
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