Postoperative Nausea and Vomiting Clinical Trial
Official title:
Effect of RightâStellate Ganglion Block on Postoperative Nausea and Vomiting in Patients Undergoing Thyroid Surgery
Postoperative nausea and vomiting is one of the most common postoperative complications second only to postoperative pain. Studies have reported that without any antiemetic prevention treatment, the overall incidence of PONV in surgical operations is up to 20-30%, and the incidence of PONV in high-risk patients such as thyroid surgery is even up to 70-80%. PONV not only increased discomfort and prolonged hospital stay; Severe cases can lead to wound dehysis, acid-base imbalance, water and electrolyte metabolism disorders, seriously affect the prognosis of patients. Although various prevention and treatment measures have been adopted in clinical practice, it still cannot be completely eliminated. Therefore, postoperative nausea and vomiting of thyroid is still a concern in clinical anesthesia work, so it is urgent to explore more simple and effective measures to prevent thyroid PONV. SGB is the injection of local anesthetics into loose connective tissue containing stellate ganglion. It has a clear effect on postoperative analgesia of thyroid surgery, and can play a certain role in preventing thyroid PONV by reducing the application of perioperative opioids. Few studies have reported that the incidence of PONV can be significantly reduced after the application of SGB in patients with thyroid surgery, which provides a certain basis for the prevention of thyroid PONV. Therefore, this study aims to explore the effect of right stellate ganglion block on preventing postoperative nausea and vomiting of thyroid, and to explore the possible mechanism of action.
Status | Recruiting |
Enrollment | 200 |
Est. completion date | August 30, 2024 |
Est. primary completion date | May 30, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 70 Years |
Eligibility | Inclusion Criteria: 1. Receiving thyroid surgery under general anesthesia 2. Age =18 years and = 70 years 3. American Society of Anesthesiologists(ASA) physical status classification I-III. 4. Voluntary participation and ability to understand and sign the informed consent form. Exclusion Criteria: 1. Patients with obesity(BMI>30 kg/m2) 2. contraindicated to stellate ganglion block 3. Patients who cannot cooperate with the study for any reason, or whom the investigator deems unsuitable for inclusion in this trial. |
Country | Name | City | State |
---|---|---|---|
China | The Second Affiliated Hospital of Chongqing Medical University | Chongqing | Chongqing |
Lead Sponsor | Collaborator |
---|---|
The Second Affiliated Hospital of Chongqing Medical University |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Incidence of Postoperative nausea and vomiting | Postoperative nausea and vomiting is evaluated by follow-up | From end of surgery to 24 hours after surgery | |
Secondary | Incidence of Postoperative nausea and vomiting during preemptive analgesia | Postoperative nausea and vomiting is evaluated by investigator's follow-up | From 0-10 min after preemptive analgesia | |
Secondary | Intensity of nausea and vomiting during preemptive analgesia | Intensity of nausea and vomiting is evaluated by numeric rating scale (0-10), which higher socre represents more uncomfortable | From 0-10 min after preemptive analgesia | |
Secondary | Intensity of nausea and vomiting during hospitalization | Intensity of nausea and vomiting is evaluated by numeric rating scale (0-10), which higher socre represents more uncomfortable | From end of surgery to 24 hours after surgery | |
Secondary | Hemodynamic parameters after preemptive analgesia | Systolic blood pressure,dastolic blood pressure,mean arterial pressure,heart rate,oxygen saturation,Patient state index | From 0-10 min after preemptive analgesia | |
Secondary | Postoperative pain intensity | Postoperative pain intensity is assessed by numeric rating scale (0-10), which higher socre represents more uncomfortable | From end of surgery to 24 hours after surgery | |
Secondary | Recovery of gastrointestinal function | Gastrointestinal function is is assessed by the evacuation time | From end of surgery to 24 hours after surgery | |
Secondary | Sleep quality | Sleep quality is is assessed by numeric rating scale (0-10), which higher socre represents better sleep quality | From end of surgery to 1 day after surgery | |
Secondary | Satisfaction score and postoperative analgesia satisfaction score | Satisfaction score and postoperative analgesia satisfaction score is assessed by numeric rating scale (0-10), which higher socre represents more uncomfortable | From end of surgery to hospital discharge with about 5 days |
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