Clinical Trials Logo

Clinical Trial Summary

A multicenter randomized controlled study of surgery combined with neoadjuvant and adjuvant therapy for locally advanced recurrent nasopharyngeal carcinoma in comparison to surgery combined with adjuvant therapy


Clinical Trial Description

Eligible patients are randomized into the control group and the experimental group. Patients in the experimental group would be administrated 2 courses of neoadjuvant therapy before surgery.After endoscopic surgery, patients would continue to receive 2-4 courses of chemotherapy and 8 courses of immunotherapy. Patients in the control group would firstly receive endoscopic surgery, followed by chemotherapy and immunotherapy. In total, 4 to 6 courses of chemotherapy and 10 courses of immunotherapy would be administrated. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06235203
Study type Interventional
Source Eye & ENT Hospital of Fudan University
Contact Xiaole Song
Phone +8621 64377134
Email jxfxsxl@163.com
Status Recruiting
Phase Phase 3
Start date May 1, 2024
Completion date June 30, 2027

See also
  Status Clinical Trial Phase
Not yet recruiting NCT06010095 - Testing Nivolumab and Ipilimumab Immunotherapy With or Without the Targeted Drug Cabozantinib in Recurrent, Metastatic, or Incurable Nasopharyngeal Cancer Phase 2
Recruiting NCT03639467 - Study of Anlotinib Combined With Gemcitabine/Cisplatin in Advanced Nasopharyngeal Carcinoma Phase 1/Phase 2
Recruiting NCT06029270 - Testing the Addition of BMS-986016 (Relatlimab) to the Usual Immunotherapy After Initial Treatment for Recurrent or Metastatic Nasopharyngeal Cancer Phase 2
Recruiting NCT03666221 - Nimotuzumab for Recurrent Nasopharyngeal Carcinoma Phase 2
Recruiting NCT05350891 - Transnasal Endoscopic Surgery Combined With Adjuvant Immunotherapy for Recurrent NPC Phase 2
Active, not recruiting NCT04586088 - Apatinib and Camrelizumab in Recurrent or Metastatic Nasopharyngeal Carcinoma With First-line Treatment Failure Phase 2
Active, not recruiting NCT04405622 - Toripalimab and Gemcitabine in Recurrent or Metastatic Nasopharyngeal Carcinoma. Phase 2
Not yet recruiting NCT04215510 - Early Recurrent Nasopharyngeal Cancer: the Effect of Surgery vs IMRT Phase 3
Recruiting NCT03907826 - PD-1 Antibody Combined With Chemoradiotherapy in Recurrent Nasopharyngeal Carcinoma Patients Phase 3
Recruiting NCT03930498 - Programmed Death-1 (PD-1) Antibody Combined With Chemoradiotherapy in High-risk Recurrent Nasopharyngeal Carcinoma Phase 2
Recruiting NCT04376866 - Toripalimab for Local-regional Recurrent Nasopharyngeal Carcinoma Phase 3
Not yet recruiting NCT05432219 - A Transoral Retropterygoid Approach to Resect Recurrent Nasopharyngeal Carcinoma N/A
Recruiting NCT04425265 - Plasma Radiofrequency Ablation at Low Temperature Versus Electrocautery Block Resection at High Frequency for Localized Recurrent Nasopharyngeal Carcinoma N/A
Not yet recruiting NCT03689556 - Examine the Prognostic Role of FLT PET/CT for Patients With LR-NPC Treated by Carbon Ion Therapy
Not yet recruiting NCT03210389 - A Clinical Trial of Chemotherapy With Lobaplatin and 5-FU in Recurrent Local or Distant Advanced NPC. Phase 2
Completed NCT01392235 - Famitinib in Treating Patients With Recurrent and/or Metastatic Nasopharyngeal Carcinoma (NPC) Phase 2
Completed NCT01370070 - MK-2206 in Recurrent Nasopharyngeal Carcinoma Phase 2
Not yet recruiting NCT06228079 - Adjuvant vs Surgery Only in Early-stage Recurrent NPC Phase 3
Terminated NCT04458909 - Testing the Addition of an Anti-cancer Immune Therapy Drug (Nivolumab) to the Usual Chemotherapy Treatment (Cisplatin or Carboplatin With Gemcitabine) for Recurrent or Metastatic Nasopharyngeal Cancer Phase 3
Withdrawn NCT04231864 - Durvalumab and Epacadostat for Treatment of Unresectable, Recurrent, or Metastatic Epstein-Barr Virus Positive Nasopharyngeal Cancer Phase 2