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Examine the Prognostic Role of FLT PET/CT for Patients With LR-NPC Treated by Carbon Ion Therapy

Recurrent Nasopharyngeal Carcinoma Clinical Trial

Official title:
A Phase II Clinical Trial Evaluating the Role of FLT PET/CT in Predicting Treatment Response of Carbon-ion Radiotherapy for Patients With Locoregionally Recurrent Nasopharyngeal Carcinoma

Clinical Trial Summary

We aim, in this study, to examine whether reduction of FLT PET derived SUV before and after carbon ion radiotherapy can predict the treatment response and survivals for patients with locoregionally recurrent nasopharyngeal carcinoma.

Clinical Trial Description

This is a single-arm phase II clinical trial evaluating the prognostic value of FLT PET/CT for patients with locoregionally recurrent nasopharyngeal carcinoma. All patients will receive FLT PET/CT scans before and after carbon ion radiotherapy (CIRT). The sensitivity and specificity of reduction of FLT uptake reduction in terms of predicting the treatment outcome evaluated by MRI at 3 months after completion of CIRT according to RECIST 1.1. Its predictive value of OS, LPFS, RPFS and DMFS will be examined as well. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03689556
Study type Observational
Source Shanghai Proton and Heavy Ion Center
Contact Lin Kong, MD
Phone +86-21-38296666
Email lin.kong@sphic.org.cn
Status Not yet recruiting
Phase
Start date July 2020
Completion date August 2024
View Details
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