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Chronic Anergic-anhedonic Depression Open Trial — CADOT  

Depressive Disorder, Treatment-Resistant Clinical Trial

Official title:
Chronic Anergic-anhedonic Depression Open Trial

Clinical Trial Summary

A form of depression called 'dopamine-sensitive anergic-anhedonic syndrome is usually resistant to standard therapies (TRAD). On the other hand, they respond to dopaminergic approaches for which recommendations have been developed: DATA ('Dopaminergic Antidepressant Therapy Algorithm'). These are two stages starting with non-selective monoamineoxidase inhibitors (MAOI) or dopamine D2 receptor agonists (D2RAG) in 'monotherapy' (DATA1) and proposing to combine them in the event of a partial response (DATA2). The effectiveness of this approach in the management of TRAD has not yet been evaluated in routine care. The aim of this study is to evaluate the feasibility and effectiveness in routine care of the DATA recommendations in the management of TRAD presenting to a specialized consultation for resistant depression (short and long-term results).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06110507
Study type Observational
Source University Hospital, Strasbourg, France
Contact Jack FOUCHER, MD, PhD
Phone 33 3 88 11 69 21
Email jack.foucher@chru-strasbourg.fr
Status Recruiting
Phase
Start date April 1, 2023
Completion date March 22, 2024
View Details
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