Myocardial Infarction With Nonobstructive Coronary Arteries Clinical Trial
— SMINC-3Official title:
Stockholm Myocardial Infarction With Nonobstructive Coronaries Study 3 - Pilot Study of Prevalence of Coronary Microvascular Dysfunction in Myocardial Infarction With Nonobstructive Coronary Arteries
The present pilot study will investigate the prevalence of CMD in an unselected cohort of patients with the working diagnosis MINOCA and to study if the diagnostic yield can be improved by adding adenosine to the CMR investigation. Patient will be their own controls.
Status | Recruiting |
Enrollment | 85 |
Est. completion date | March 31, 2024 |
Est. primary completion date | December 31, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 35 Years to 79 Years |
Eligibility | Inclusion Criteria: - a suspected diagnosis of MINOCA or takotsubo syndrome with coronary angiography without diameter stenosis =50% - age 35-80 years - reading and writing proficiency in Swedish Exclusion Criteria: - Claustrofobia - Arrythmia and/or pacemaker (atrial fibrillation and AV-block I- III) - Asthma or severe chronic obstructive lung disease - eGFR < 30 ml/min - spontaneous coronary artery dissection - acute pulmonary embolism - acute myocardial infarction type 2 - cardiomyopathy other than takotsubo syndrome - a previous myocardial infarction due to CAD |
Country | Name | City | State |
---|---|---|---|
Sweden | Per Tornvall | Stockholm |
Lead Sponsor | Collaborator |
---|---|
Karolinska Institutet | Region Stockholm |
Sweden,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Diagnostic yield | To increase the diagnostic yield of CMR imaging in MINOCA as a working diagnosis | Through investigation completion, usually 2 hours | |
Secondary | Prevalence of CMD in MINOCA | To determine the proportion of patients with the working diagnosis of MINOCA who have CMD. | Through investigation completion, usually 2 hours | |
Secondary | Prevalence of CMD in different final MINOCA diagnoses | To study the proportions of CMD in patients with a CMR imaging diagnosis of myocardial infarction, Takotsubo, respectively myocarditis and compare them with the results from a healthy control group | Through investigation completion, usually 2 hours | |
Secondary | Angina pectoris | To investigate the occurrence of angina pectoris before inclusion and after 3 months and relate it to CMD | 3 Months |
Status | Clinical Trial | Phase | |
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