Clinical Trials Logo
  1. Home
  2. Other
  3. NCT04723030

The Transformation of Locally Advanced Pancreatic Cancer.

Locally Advanced Pancreatic Cancer Clinical Trial

Official title:
Carrilizumab Combined With Apatinib Mesylate and Radiotherapy and Chemotherapy for the Transformation of Locally Advanced Pancreatic Cancer.

Clinical Trial Summary

This trial will explore the efficacy and safety of camrelizumab combined with apatinib mesylate and radiotherapy and chemotherapy (paclitaxel (albumin binding) combined with gemcitabine and cisplatin) in the treatment of locally advanced pancreatic cancer in patients with locally advanced pancreatic cancer.

Clinical Trial Description

This trial is a prospective, observational, single-center, single-arm clinical research.Conversion treatment lasted for a total of 12 weeks, with one treatment cycle every two weeks.Carilizumab was administered every 2 weeks. The patients were orally taken apatinib after meals and evaluated by DLT(3+3) in the first 2 cycles.The drugs were stopped for 2 weeks after the start of radiotherapy.Before radiotherapy, patients received 2 cycles of karyolizumab combined with apartinib and chemotherapy. Radiotherapy was performed in the first week of cycle 3 with a total dose of 30Gy in five doses within one week.Imaging evaluation was conducted once every 6 weeks. If the patients met the indications for surgical resection, the treatment was stopped ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04723030
Study type Interventional
Source Peking University
Contact JUN ZHOU, MD
Phone 01088121122
Email joelbmu@163.com
Status Not yet recruiting
Phase Phase 2
Start date April 1, 2021
Completion date April 1, 2023
View Details
See also
  Status Clinical Trial Phase
Terminated NCT03600623 - Folfirinox or Gemcitabine-Nab Paclitaxel Followed by Stereotactic Body Radiotherapy for Locally Advanced Pancreatic Cancer Early Phase 1
Completed NCT01628458 - Safety Study of Radiofrequency Ablation of Locally Advanced Pancreatic Cancer Phase 2
Not yet recruiting NCT04276857 - Systemic Therapy With a Loco-regional Treatment in Patients With Locally Advanced Pancreatic Cancer N/A
Not yet recruiting NCT05988372 - Surufatinib and Serplulimab Combined With AG Regimen Compare With AG Regimen as Conversion Therapy for Patients With Locally Advanced Pancreatic Cancer (SAGE) Phase 2
Completed NCT00744640 - Gemcitabine, Oxaliplatin and Capecitabine for Advanced Pancreatic Carcinoma Phase 1/Phase 2
Completed NCT03126435 - EndoTAG-1+GEM vs GEM in Patients With Locally Advanced/Metastatic Pancreatic Adenocarcinoma Failed on FOLFIRINOX Phase 3
Completed NCT02035072 - Phase II Study of Hypofractionated Radio-chemotherapy With Gemcitabine Plus Oxaliplatin for Unresectable Nonmetastatic Locally Advanced Pancreatic Cancer. Phase 2
Enrolling by invitation NCT01063192 - A Study of Locally Advanced Pancreatic Cancer Phase 2
Active, not recruiting NCT06429904 - Nimotuzumab Plus NALIRIFOX in Locally Advanced Pancreatic Cancer Phase 2
Recruiting NCT03885219 - Nab-paclitaxel and S-1 in Patients With Locally Advanced Pancreatic Cancer Phase 2
Active, not recruiting NCT03468335 - 2nd-line Therapy With Nal-IRI After Gem/Nab-pac in Advanced Pancreatic Cancer - Predictive Role of 1st-line Therapy Phase 3
Not yet recruiting NCT03443921 - Divestment for Artery-involved Pancreatic Cancer N/A
Recruiting NCT03257033 - Intra-arterial Gemcitabine vs. IV Gemcitabine and Nab-Paclitaxel Following Radiotherapy for LAPC Phase 3
Completed NCT02578732 - FOLFOX-A For Locally Advanced Pancreatic Cancer: A Phase II Brown University Oncology Research Group Trial Phase 2
Recruiting NCT04789980 - Good Choice of pALliative Chemotherapy to Patient With Pancreatic Cancer ; GemcitAbine Therapy vs FOLFORINOX therapY
Completed NCT00644618 - Randomized Controlled Trial of Gemcitabine Combined With 125I Brachytherapy Phase 3
Recruiting NCT03682289 - Ceralasertib (AZD6738) Alone and in Combination With Olaparib or Durvalumab in Patients With Solid Tumors Phase 2
Terminated NCT02404363 - Safety and Efficacy of Clopidogrel in Locally Advanced and Metastatic Pancreatic Adenocarcinoma Treated With Chemotherapy Phase 3
Active, not recruiting NCT06353581 - Prophylactic Administration of Neulapeg (Pegteograstim) in Patients With Locally Advanced or Metastatic Pancreatic Cancer Receiving the Modified FOLFIRINOX Phase 2
Not yet recruiting NCT03815461 - Nab-paclitaxel Combined With S-1 as Induction Therapy for Locally Advanced Pancreatic Cancer Phase 2