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Intra-arterial Gemcitabine vs. IV Gemcitabine and Nab-Paclitaxel Following Radiotherapy for LAPC — TIGeR-PaC  

Locally Advanced Pancreatic Cancer Clinical Trial

Official title:
Targeted Intra-arterial Gemcitabine vs. Continuation of IV Gemcitabine Plus Nab-Paclitaxel Following Induction With Sequential IV Gemcitabine Plus Nab-Paclitaxel and Radiotherapy for Locally Advanced Pancreatic Cancer

Clinical Trial Summary

The study is a multi-center, un-blinded, randomized control study of subjects with locally advanced pancreatic adenocarcinoma which is unresectable.

Clinical Trial Description

All subjects will receive induction therapy of IV gemcitabine plus nab-paclitaxel, as well as radiation therapy for approximately four months. Subjects who remain eligible will then be randomized to receive either intra-arterial chemotherapy with gemcitabine; or to continue gemcitabine plus nab-paclitaxel. Subjects will receive the randomized treatments for up to 16 weeks or until progression. Both groups will receive either IV gemcitabine and nab-paclitaxel or oral capecitabine following the 16 week treatment course until disease progression at the discretion of the Investigator. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03257033
Study type Interventional
Source RenovoRx
Contact Carter Hultman
Phone 6502844433
Email chultman@renovorx.com
Status Recruiting
Phase Phase 3
Start date March 12, 2018
Completion date September 2023
View Details
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