Gram-Negative Bacterial Infections Clinical Trial
Official title:
Comparison of Solid Organ Transplant Specific and Hospital-wide Gram-Negative Antibiograms
Solid organ transplant (SOT) recipients have increased incidence of infections with MDRO pathogens. This difference leads to a disparity in antibiograms between SOT recipients and other hospitalized patients.
There is limited guidance for empiric antimicrobial therapy in this population. Local
epidemiology plays a voluble role in managing infections empirically within the hospital
setting. Antibiograms can serve as a critical tool in optimizing empiric antimicrobial
decisions. Refining antibiogram data to specific populations such as SOT patients may allow
for timelier and appropriate empiric use of antimicrobials, and improve clinical outcomes.
Time to appropriate therapy (antimicrobial testing susceptible in vitro to the pathogen
identified) is of vital importance in management of serious infections. SOT may have
different resistance rates at Methodist Dallas Medical Center making the applicability of the
yearly hospital-wide antibiogram unknown for use in this specialized patient population. A
SOT-Specific antibiogram may highlight common resistance patterns identified in pathogens
seen in this patient population. Additionally, this investigation may further emphasize the
importance of antimicrobial stewardship activities such as: appropriate empiric antibacterial
decisions, de-escalation, and effective durations of therapy.
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