Chronic Thromboembolic Pulmonary Disease Clinical Trial
Official title:
Symptom-driven Referral for Evaluation of Chronic Thromboembolic Disease or Pulmonary Hypertension in Patients With Previous Acute Pulmonary Embolism
Aim: To investigate if a symptom driven referral for chronic thrombosis in the lungs after
acute pulmonary embolism is better than the current approach.
Background: A number of patients with chronic thrombosis in the lungs after acute pulmonary
embolism have dyspnea and reduced functional capacity without elevated pulmonary arterial
pressure at rest (CTED). However, current guidelines for follow-up after acute pulmonary
embolism will miss all patients with CTED, as referral for further examination is based on
elevated pulmonary arterial pressure on echocardiography. Thus, the prevalence of CTED is
unknown. The hypothesis is, that a symptom-driven referral of patients with previous acute
pulmonary embolism is more sensitive in diagnosing CTED than the current approach.
Methods and materials: Patients diagnosed with acute pulmonary embolism in Region Midt
(approx. 350 per year) will be screened for non-recovery or persistent pulmonary embolism
related symptoms during their 3-6 months follow up at their local outpatient clinic. If the
patient has persistent symptoms they will be referred to a scintigraphy. If CTED is suspected
from the scintigraphy, the patient will be referred for full CTED work-up. The investigators
expect to screen 300 patients for persistent symptoms with an expected study time of 3 years.
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